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Immuno ch9: autoimmunity
LECOM 2015 PBL Immunology chapter 9
8
Medical
Graduate
03/23/2012

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Cards

Term
role of AIRE in autoimmunity gene
Definition
disease assoc: autoimmune polyendocrine syndrome

mechanism: defective expression of tissue antigens and elimnation of self-reactive T cells in the thymus
Term
role of complement proteins C2 and C4 in autoimmunity
Definition
disease: LUPUS like disease
Mechanism: defective clearnace of immune complexes; or defects in B cell tolerance
Term
role of Fas, FasL in autoimmunity?
Definition
disease: Lpr, gld mouse strains; human ALPS
defective elimination of self reactive lymphocytes
Term
role of Fc(gamma)RIIb
Definition
disease: lupus like disease
mech: defective feedback inhibition of B cell activation
Term
Foxp3
Definition
disesae: X-linked polyendocrinopathy and enteropathy (IPEX)
mechanism: deficiency of regulatory T cells
Term
IL-2 and IL-2Ra/b
Definition
disease: several autoimmune diseases with increased risk of polymorphisms
mechanism: deficiency of regulatory T cells
Term
role of NOD-2 in autoimmune disease
Definition
disease: Crohns
Mech: defective resistance or abnormal responses to intestinal microbes
Term
role of PTPN22 in autoimmune disease
Definition
disease: several
mechanism: abnormal tyrosine phosphatase regulation of lymphocyte activation
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