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Immune System - B Lymphocyte Development
Dr Payne 12/1/10
41
Medical
Professional
12/04/2010

Additional Medical Flashcards

 


 

Cards

Term

 

- early fetal B cell development occurs in this organ from hematopoietic stem cells (HSC)

Definition

 

Fetal Liver

Term

- the site of B cell activation
Definition

 

Secondary Lymphoid Organs

Term

 

- cytokine receptors that orchestrate B cell development

Definition

 

Flt, IL-7 receptor

Term

 

- B cell lineage specific transcription factors

Definition

 

EBF, PAX-5

Term

 

- Genes that control Ig gene rearrangement

Definition

 

RAG-1, RAG-2, TdT

Term

 

- these type of cells found in bone marrow influence (dependency) B cell development

- cytokines (Flt ligand, IL-7) are produced/recepted by these

Definition

 

Stromal Cells

Term

 

- B cells (and blood) originate from these cells that are initially found in the fetal liver

Definition

 

Hematopoietic stem cells (HSCs)

Term

 

- this protein surface marker is found on HSCs and most progenitor cells

Definition

 

CD34

Term

 

- this protein surface marker is specific for the B lineage and the point at which they begin the pro-B stage

Definition

 

CD19

Term

 

- this drug is used to deplete B cells in the circulation by means of complement dependent cytotoxicity, antibody-dependent cytotoxicity, and apoptosis

Definition

 

anti-CD20 (Rituximab)

Term

 

- respectively what heavy chain rearrangement occurs in the early and late pro-B cell stage

Definition

 

D-->J then V-->DJ

Term

 

- this process fails to give rise to a functional Ig protein (sometimes because of a premature stop codon)

Definition

 

Nonproductive rearrangement

Term

 

- the three primary components of the pre-B cell receptor

Definition

 

cmew, surrogate light chains (invariant), Iga and Igb

Term

 

- this process that is stimulated by a pre-BcR signal results in only one IgH chain allele expressed (single specificity)

- helps promote survival/homogeny

Definition

 

Allelic exclusion

Term

 

- in this stage pre-B cells undergo rapid cell division until is halted so that the light chains can rearrange (V-->J)

- there are two substages (Large-->Small)

Definition

 

Pre-B cell stage

Term

 

- this domain is responsible for mediating the process that Iga and Igb initiate following antigen binding

Definition

 

immunoreceptor tyrosine-based activation motif (ITAM)

Term

- a BCR (after pre-B cell stage) consists of these three things
Definition

 

cmew, light chain (k or l), and Iga and Igb

Term

 

- this stage of B cell development could contain transitional stages of development (IgM only) after the BCR is expressed

Definition

 

Immature B cell stage

Term

 

- site of B cell maturation

Definition

 

Spleen

Term

 

- during this stage of B cell development splicing allows for IgD to be produced as well as IgM

Definition

 

Mature (Naive) B cell stage

Term

 

- the two checkpoints that occur during B cell development before and after the pre-B cell stage check for proper expression of these two components

Definition

 

heavy chain (1st) and light chain (2nd)

Term

 

- these cells express CD5 and arise in embryonic development

- do not have somatic hypermutation or memory

- T-independent

- dominant B cells in lung and abdominal cavities

- maintained in adults by self renewal (mitosis?)

Definition

 

B-1 Cells

Term

 

- this surface protein can be a marker of activated B cells, "transitional" B cells, and chronic lymphocytic leukemia

Definition

 

CD5

Term

 

- cells that generate IgM+ memory cells

- resemble mice B1 cells in specificity and function

Definition

 

Marginal Zone B cells

Term

 

- percentage of B cells that are autoreactive at the immature B cell stage and must be eliminated

Definition

 

75%

Term

 

- the two alternatives that will make an autoreactive B cell unproductive following self-antigen recognition

- binds multi-valent surface antigen and soluble antigen respectively

Definition

 

Clonal deletion & Anergy (long term inactivation)

Term

 

- the process by which light chains can rearrange after their initial arrangement to be able to avoid death or inactivation following self-antigen recognition

Definition

 

Receptor editing

Term

 

- upregulatation of expression of receptors for this cytokine helps to promote survival by upregulation expression of BCL-XL following a lack of autoreactivity

Definition

 

BAFF (B cell activating factor)

Term

 

- the current difference between central and peripheral tolerance is that this process does not occur peripherally

Definition

 

Receptor editing

Term

 

- direct homing of B cells in the blood to secondary lymphoid tissues through T cell zones and into primary lymphoid follicles (germinal centers)

Definition

 

Chemokines

Term

 

- these cells are not hematopoietic in origin and touch B cells with their long processes

- make up network of stromal cells in primary lymphoid follicles

Definition

 

Follicular dendritic cells

Term

 

- B cell responses to most antigens are thymus dependent and require these type of cells

Definition

 

CD4 helper T cells

Term

 

- activated B cells that differentiate into plasma cells and produce IgM are found in this location in the lymph node

Definition

 

medullary cords of secondary lymphoid tissue

Term

 

- this cell type makes antibodies but does not have any surface receptors of its own

- found in medullary cords of secondary lymphoid tissue

Definition

 

plasma cell

Term

 

- primary lymphoid follicles that contain activated B cells differentiate into this that contains a germinal center

Definition

 

secondary lymphoid follicle

Term

 

- the germinal center has B cells that become these type cells that proliferate and undergo somatic hypermutation and class switching

- become centrocytes after maturity

Definition

 

Centroblasts

Term

- this process utilizes Darwinian principles to increase the overall affinity of antibodies for a specific antigen
Definition

 

Affinity Maturation

Term

 

- persist for a long period of time with only intermittent stimulation in the primary follicle

- quicker/stronger response to antigen than with the primary response

Definition

 

Memory B cells

Term

 

- the conversion B cells into tumor cells in Burkitt's lymphoma and other non-B cell tumors comes from mistakes in gene splicing during Ig gene rearrangement that result in this

Definition

 

Translocations

Term

 

- plasma cell tumors that propagate in the bone marrow

Definition

 

Myeloma

Term

 

- tumors derived from mature naive B cells

- retain the characteristic of the mature naive B cell during abnormal growth

Definition

 

Follicular center cell lymphoma

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