Shared Flashcard Set

Details

Immune System - B Cell Immunity
Dr Payne 12/8/10
22
Medical
Professional
12/09/2010

Additional Medical Flashcards

 


 

Cards

Term

 

- B-cell activation utilizes surface IgM to do this in order to be activated through the ITAMs and tyrosine kinase pathways

Definition

 

Clustering (Congregation/Cross-linking)

Term

 

- these two B-cell co-receptors that bind CR2 are required in order fully activate B cells

Definition

 

CD21, CD19

Term

 

- this surface co-receptor is phosphorylated in order to bind intracellular signaling molecules

Definition

 

CD19

Term

 

- T-dependent B cell activation signals come from these three correlated cell/receptors

Definition

 

BCR, B cell co-receptor, CD40/CD40 L

Term

 

- T-1 antigens are thymus-independent and utilize these signals to activate B cells

Definition

 

bind toll-like receptors (TLRs) - LPS, bacterial DNA

act as mitogens (nonspecific activation)

Term

 

- T-2 antigens have this characteristic that makes additional signals unneeded

Definition

 

repetitive carbohydrate chains that induce extensive clustering

Term

 

- Immature Dendritic cells, through maturity and antigen presentation activate CD4 T cells to become these

Definition

 

helper TH2 cells

Term

 

- these molecules are upregulated following a B cell encounter with a specific antigen to prevent B cell migration from the lymph node

Definition

 

Adhesion molecules & chemokine receptors

Term

 

- this interaction is between B and T cells specific to the same antigen

Definition

 

cognate interaction

Term

 

- this is formed between activated B and T cells following CD40/CD40L binding so that cytokines can be transferred

Definition

 

Immunological synapse

Term

 

- the transcription factor that turns off B cell genes and activates plasma cell differentiation following migration to the medullary cords

Definition

 

BLIMP-1

Term

 

- after binding immune complexes (antigen with complement) these cells can retain them for months or years on their surface

Definition

 

Follicular Dendritic Cells

Term

 

- affinity maturation is driven by these cells in the germinal center

Definition

 

Centrocytes

Term

 

- patients that lack CD40L suffer from this

Definition

 

Hyper-IgM syndrome

Term

 

- IL-10 is the primary helper T cell cytokine that promotes formation of these cells

Definition

 

plasma cells

Term

 

- memory B cell production is stimulated by this cytokine

Definition

 

IL-4

Term

 

- babies are particularly vulnerable during this time period due to loss of new mother antibodies and decreased production of their own

Definition

 

3-6 months of age

Term

 

tetanus and dihptheria vaccines utilize these molecules

Definition

 

Toxoids (modified toxins)

Term

 

- C4 deficiency is associated with many immunodeficient diseases (examples)

Definition

 

C4a (lupus), C4b (lowered resistance)

Term

- surface receptor that erythrocytes use to bind immune complexes and take them to the liver and spleen to be degraded
Definition

 

CR1 (complement receptor 1 bind C3b)

Term

 

- NK ells recognize and kill cells coated with IgG1 or IgG3 by this

Definition

 

ADCC (antigen-dependent cell-mediated cytotoxicity)

Term

 

- this antibody type has a different Fc receptor family than the others

 

Definition

 

IgA

Supporting users have an ad free experience!