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HIV therapeutics, Chemo, supplements
n/a
24
Pharmacology
Professional
04/26/2014

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Cards

Term
MOA for cyclophosphamide?
Definition
-bifunctional alkylating agent that preferentially alkylate N-7 of guanine base which interferes with DNA replication by forming intrastrand and interstrand DNA cross links
-first activated by P450 microsomal enzymes
Term
Is cyclophosphamide CCNS or CCS?
Definition
CCNS
Term
Which alkylating agents are CCNS?
Definition
Cyclophosphamide, Ifosphamide, Temozolomide, Cisplatin, Carboplatin, Oxaliplatin
Term
Which alkylating agents are M-phase specific?
Definition
Vincristine, Vinblastine, Vinorelbine, Paclitaxel, albumin-bound Paclitaxel, Cabazitaxel, Docetaxel
Term
Which alkylating agents are G1-S phase specific?
Definition
Etoposide
Term
What are the SE of cyclophosphamide?
Definition
Nausea, vomiting, hair loss, myelosuppression, hematuria (mitigate by administering drug in the morning, frequent urination and maintain hydration)
Term
Define the utility of mesna when administered with an alkylating agent.
Definition
Cyclophosphamide and ifosphamide are coadministered with mesna to prevent hemorrahagic cystits. Mesna is an inactive dimer in the blood and cells. In the urine, mesna is an active monomer that binds to alkylating agent species in the urine preventing their toxic effect on urothelium.
Term
Which platin drug is dose-limited by renal toxicity? How can this be avoided?
Definition
cisplatin
-give a saline/mannitol diuresis (chloruresis) before administering
Term
Which platin drugs are not renal toxic?
Definition
carboplatin and oxaliplatin
Term
Which platin drug causes hypomagnesemia?
Definition
cisplatin
Term
Which platin drug causes CN VIII damage leading to high freq hearing loss?
Definition
cisplatin
Term
Which platin drug has a unique dose calculation?
Definition
carboplatin
Dose(mg) = AUC x (GFR+25)
Term
What platin drugs are dose limited by myelosuppression?
Definition
carboplatin and oxaliplatin
Term
What platin drug causes sensory neurotoxicity - both acute cold induced neuropathy and chronic sensory neuropathy?
Definition
oxaliplatin
Term
What is the MOA of vincristine?
Definition
inhibits mitotic spindle formation in the M-phase
"microtubules are the VINes of your cells"
Term
What is the MOA of paclitaxel?
Definition
prevents breakdown of the mitotic spindle in the M-phase
"it is TAXing to stay polymerized"
Term
What is the MOA of etoposide?
Definition
Inhibits topoisomerase II causing DNA strand breakage in G1-S phase
Term
What is the most common side effect of vincristine?
Definition
peripheral neuropathy
Term
What alkylating agent can cause hyponatremia due to stimulation of ADH release?
Definition
vincristine
Term
What chemo drug is associated with increased incidence of leukemia at doses >2gm/M2?
Definition
Etoposide
Term
What is the dose limiting SE of paclitaxel?
Definition
myelosuppression
Term
What is the dose limiting SE of etoposide?
Definition
myelosuppression
Term
What chemo agent can cause severe hypersensitivity rxns & pts receiving this drug must be premedicated with steroids, diphenhydramine and an H2 blocker?
Definition
paclitaxel
Term
What alkylating agents require dose modification dur to renal insufficiency or jaundice?
Definition
vincristine -- do NOT give with hepatic damage/signs of jaundice
Paclitaxel -- dec dose with hepatic dysfunction
Etoposide -- dec dose with hepatic or renal dysfunction
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