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HIV Entry Inhibitors CCR5 Antagonists Inegrase Inhibitors
HIV Entry Inhibitors CCR5 Antagonists Inegrase Inhibitors
14
Pharmacology
Professional
10/01/2012

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Cards

Term
How do entry inhibitors work
Definition

Inhibits the fusion of the HIV-1 virus with the CD4 cells by blocking the conformational change in gp41

Term
Name an entry inhibitor
Definition
Enfurvitide
Term
Brand name for enfurvitide
Definition
Fuzeon
Term
How is Fuzeon administered
Definition
injection
Term
[image]
Definition
Statement. Not a question.
Term
How do CCR5 Antagonists work
Definition

Binds to the CCR5 receptor on the CD4 cells and prevents the conformational change required for cell entry

Term
Name the CCR5 antagonists
Definition
Maraviroc
Term
Brand name for Maraviroc
Definition
Selzentry
Term
What test must be performed prior to starting Maraviroc
Definition

Topism test to determine the "tropism" of their HIV since this agent will not work for patients with CXCR4 - tropic disease or in HIV that uses a combo of both coreceptors

Term
[image]
Definition
Statement. Not a question.
Term
How do integrase inhibitors work
Definition

inhibits the catalytic activity of HIV-1 inegrase, thus preventing the insertion of HIV DNA into the host genome and virus cannot replicate

Term
Name a inegrase inhibitor
Definition
Reltegravir
Term
Brand name for Reltegravir
Definition
Isentress
Term
[image]
Definition
Statement. Not a question.
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