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Hepatitis B Virus
Hepatitis B Virus
15
Medical
Graduate
09/10/2010

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Cards

Term
What type of vaccine is Hepatitis B ?
Definition
Recombinant. Other recombinant vaccines are HPV and S. typhi. Ag are produced via a yeast cell
Term
Hepatitis B efficacy?
Definition
It varies. Better in infants with 98-100% after 3 doses, than in adolescents and adults with 90-95%.
Term
Which vaccines ares stored at 2-8C?
Definition
Hep A, Hep B and Tetanus, Diphteria and Pertussis.
Term
Epi Hepatitis B Virus
Definition
The most common viral infection. 300 million are chronic carriers. 1/3 of pop with evidence of past or continuing infection. 15-25% of infected will die of liver causes (cirrhosis or HCC). Causes 80% of HCC. 1 mill people die/yr of diseases related to HBV infection.
Term
HBV, who has more risk of chronic disease?
Definition
Children. They are less symptomatic than adults, but have a much higher risk of developing chronic infection
Term
HBV transmission
Definition
sex, blood transfusion, perinatal (+F in L-MIC, especially in mother HBeAg+). 50-100 times more infectious than hiv
Term
HBV Kabul
Definition
6.5% prevalence in IDU
1.5 in pregnant women
Term
HBV refugees
Definition
Pakistan 2006. Prevalence of 8.3%. RF id was receiving > than 10 medical injections in previous year (Quddus)
Term
Risk factors for HBV?
Definition
non medical injections (2003 Pakistan). Low knowledge and awareness of HBV among pregnat women
Term
Global HBV epi?
Definition
Endemic in China and SEA with 8-20% of people with chronic infection. Central Asia with 2-7% prev of chronic infection
Term
Effect of HIV on HBV
Definition
Increased level of HBV DNA
In people tx with ART, reconsitution syndrome may reactivate HBV with
People signifacnt liver damage
People antiHBc postive who are infected with HIV have higher rate of reactivation of HBV
Livr related mortality 17X higher in HIV infected (MACS)
Term
Methods of HBV diagnosis?
Definition
RPHA: reverse passive hemaglutination
EIA: Enzyme immunoassay
RAI: radioimmunoassay
Term
Modes of transmission?
Definition
+F: perinatal
non-medical injections
IDU
blood transfusions
Term
Is HBV present in semen?
Definition
Yes, bu 100-1000 fold lower concentration than in blood.
Term
What is the effect of HBV on HIV infection?d
Definition
Rate of serconversion to HIV 2 fold higher in MSM HBV infected (MACS).
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