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Hemotology
Hemotology
50
Physiology
Not Applicable
06/04/2010

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Term
Total Blood Volume
Definition
8% of body wt in kg
convert lbs to kg by / by 2.2
.08 x 70kg
5.6L
Term
hematocrit
Definition
% packed cell volume
45%
Term
plasma
Definition
55%
Term
anemia
Definition
low number of normal red blood cells
Term
55% of 5.6 L
Definition
plasma is more than 2 liters of coke
Term
polycythemia
Definition
65% hematocrit
Term
Buffy coat
Definition
white cells less than 1% and platelets
Term
blood plasma composition
Definition
90% water
7g/100 ml bld 7% plasma ( protein) =70g/L
Term
albumin
Definition
60% of plasma proteins and maintains plasma volume by osmotically drawing water into bld stream
Term
prothrombin fibrinogen
Definition
blood clotting proteins - 5% of plasma proteins
Term
globulins
Definition
35% of plasma proteins
a globulins transport High Density Lipoproteins
b globulins transport low density lipoproteins and transferrin
g globulins - produce antibodies
Term
transferrin
Definition
transport iron
Term
y globulins gamma globulins
Definition
synthesized by lymphocytes
IgG act on bacteria and other foreign agents
IgE act on Allergens
Term
white blood cells
Definition
leukocytes
Term
leukopenia
Definition
too low -HIV chemotherapy
Term
leukocytosis
Definition
too high fighting infection
Term
granular leukocytes polymorphonuclearcytes
Definition
granular, multilobed, produced in red bone marrow
neutrophils , eosinophils,basophils
Term
neutrophils
Definition
60% of leukocytes
Term
eosinophils
Definition
allergic reactions
Term
basophils
Definition
produce histamine and heparin (anticoagulant)
Term
organic molecules in blood in blood plasma
Definition
glucose 70-120
cholesterol <200mg
Term
waste products
Definition
NH3, urea BUN, uric acid, creatine, bilirubin
Term
minerals
Definition
NA+, K+, Ca+2, HCO3 (buffer)
Term
serum
Definition
blood plasma w/o clotting proteins
Term
hemophilia
Definition
genetic inability to synthesize blood clotting proteins
Term
red blood cells
Definition
may have recognition site proteins called antigens
5million /mm3 blood
Term
RBC
Definition
transport O2 &CO2 by binding to hemoglobin
Term
RBC
Definition
produced in red bone marrow of vertebrae & rib cage. live for four months
Term
Erythropoeitin
Definition
hormone released in kidneys stimulates erythropoeisis in bonemarrow
Term
iron def anemia
Definition
iron binds to hemoglobin
Term
aplastic anemia
Definition
degeneration of red bone marrow
Term
thrombocytes
Definition
blood platelets (cell fragments) produced in red bone marrow. Stimulated by Thrombopoietin hormone from the liver.
Term
reticulo-endothelial system
Definition
the spleen and liver filter out old damaged RBC
Term
hemostasis
Definition
1. vascular spasm
2. formation of blood platelet plug via platelet adhesion and aggregation.
3. formation of Fibrin Protein Clot (coagulation)
Term
formation of fibrin protein clot
Definition
1. intrinsic pathway: bld platelets,platelet factor,prothrombinase
2. Extrinsic pathway: injured tissue cells, tissue factor, prothrombinase
common pathway: prothrombin + ( prothrombinase +Ca2)=thrombin. thrombin+ fibrinogen= fibrin clot
Term
fibrinolysis
Definition
to dissolve clot
plasminogen (made in liver) + TPA (released from healing cells) =plasmin =fibrinolysis
Term
Leukocytes
Definition
WBC 7,000/ mm3 blood
leukopenia / leucocytopenia/lower than normal HIV chemotherapy
leukocytosis higher than norma, fighting off infection
Term
polymorphonuclearcytes/ granular leukocytes
Definition
granular leukocytes are multilobed.
60% of WBC are neutrophils attack bacteria
eosinophils - allergic reactions
basophils - release histamine -inflammation
and release heparin - anticoagulant
Term
agranular leukocytes
Definition
monocytes - macrophages- large phagocytes
lymphocytes 25%( leukocytes /WBC) org. lymph
B lymphocytes -org. Bone marrow
T lymphocytes - org Thymus gland
Term
B lymphocytes
Definition
synthesize & release immunoglobulins (bacteria)
precipitation & agglutination- clumping
opsonization - marking for phagocytosis
lysis- activating Tc cells to lyse foreign body
Term
T lymphocytes
Definition
Th helper T Cells release interferon
release cytokines- activate B lymphocytes to ...
Tc cytotoxic T cels -release perforin
Term
Agglutination
Definition
Agglutinogens(antigens on surface of RBC) +
Agglutinins (antibodies in plasma) cause . . .
Term
release heparin and histamine
Definition
basophils (a type of granular leukocytes /WBC )
Term
release cytokines
Definition
Th Helper T lymphocytes
Term
all involved in allergic reactions
Definition
eosinophils, b lymphocytes, Th Helper T lymPhocytes, basophils, Tc Cytotoxic lymphocytes
Term
histamine
Definition
increases capillary permeability
Term
phagocytize antigen-antibody complexes in allergic reactions
Definition
Eosinophils
Term
when B lymphocytes come in contact with foreign agents they transform into
Definition
plasma cells that release antibodies
Term
basophils are also called
Definition
mast cells
Term
monocytes that leave the bloodstream
Definition
enter the tissue as macrophages
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