Shared Flashcard Set

Details

Hemo 201-2 - Leukemia
68K - Heme 201 - 2 - Leukemia
14
Medical
Not Applicable
02/01/2012

Additional Medical Flashcards

 


 

Cards

Term
What is the term described as the growth and proliferation of one or more clones of abnormal cells?
Definition
Malignancy
Term
Myeloid:Erythroid (M:E) Ratio
Definition

Ratio of the number of mature and immature granulocytes to the number of mature and immature RBCs.

Normal range 2:1 to 4:1 in adults.

Term
Neoplasm
Definition
New and abnormal formation of tissue such as a tumor or growth.
Term
What is Leukemia?
Definition

Malignant disease of hematopoietic tissue caused by the mutation of the bone marrow

Characterized by the replacement of normal bone marrow elements with abnormal (neoplastic) blood cells.

Term
Leukemic cells can infiltrate which three organs?
Definition
Spleen, Liver, and Lymph Nodes.
Term
What is the difference between leukemia and lymphoma?
Definition
In leukemia, abnormal cells are present in both the bone marrow and peripheral blood.  In lymphoma, abnormal growth of cells is confined to the lymphatic tissue.
Term
General Etiology of Leukemia
Definition

Exposure to ionizing radiation

Chemical agents

Viruses

Genetic Factors

Age

Race

Term
What are chemical agents associated with leukemia?
Definition

Benzene and cytotoxic alkylating agents, i.e. chemotherapy drugs

Alkylating agents used to treat neoplasm

Term
What viruses are associated with Leukemia?
Definition

Epstein-Barr virus ( a DNA virus)

Human T-cell Lymphotrophic Virus

Term
Describe the genetic factors and their relation to the eitology of leukemia.
Definition

Leukemia does not appear to be inherited, however, tends to cluster in families (particularly childhood twins)

Increased in persons with congenital chromosomal abnormalities as in Down's Syndrome.

Term
True or False?  Age is clinically important in the diagnosis of leukemia.
Definition
True, because different leukemias affect different age groups. 
Term
General symptoms of Leukemia
Definition

Splenomegaly, hepatomegaly, and enlargement of the lymph nodes.

Anemia and thrombocytopenia. 

Infections, fever, weight loss, and malaise.

Death typically occurs due to infections and hemorrhages in the later acute and chronic stages.

Term

Acute vs Chronic leukemia

 

Age

Definition

Acute - all ages

Chronic - Adults

Term

Acute vs Chronic Leukemia

 

Onset

Definition

Accute - Sudden/Rapidly

Chronic - Symptoms of long duration

Supporting users have an ad free experience!