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Heme/Onc
Leukemias and Lymphomas
37
Medical
Graduate
11/14/2009

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Cards

Term
These lymphomas are CD10+ and CD20+
Definition
Follicular lymphoma and Burkitt's Lymphoma have these two cell surface markers
Term
This leukemia is CD20+ and CD103+
Definition
Hairy Cell Leukemia has these two cell surface markers
Term
These two leukemias/lymphomas are CD20+ and CD5+
Definition
SLL/CLL and Mantle Cell lymphoma share these cell surface markers
Term
This NHL almost always has a t(14:18) mutation, leading to the over expession of BCL-2
Definition
Mutation of Follicular Lymphoma
Term
This NHL is the only one where a direct blood test can be diagnostic. Sx include hypercalcemia, renal failure, anemia, and bone lesions (CRAB).
Definition
Sx of Multiple Myeloma
Term
This lymphoma has delicate neoplastic cells, which create 'smudge cells' when put on glass slides
Definition
Diagnostic feature of SLL (if confined to nodes) or CLL (if luekemic phase is present) under the microscope
Term
The most common adult leukemia, a 17p deletion gives the worst prognosis. Results in hypogamaglobulinemia, with 50% of deaths resulting from infection
Definition
This deletion gives the worst prognosis for SLL/CLL, which is CD 5, 20 and 23 +
Term
This CD19, CD20 + lymphoma generally has a mutation in the BCL-6 regulatory region, or a c-MYC mutation. It enjoys spreading to the waldeyer ring (oropharyngeal lymphoid tissue).
Definition
Diffuse Large B-Cell Lymphoma (DLBCL) has these genetic mutations and spreads to this area
Term
The endemic form is associated with EBV and affects the jaw and abdominal visvera
Definition
Endemic Burkitt's lymphoma is associated with this virus and affects these parts of the body
Term
This disease usually has a t(8:14) mutation involving c-MYC and IgH. P53 is often also lost.
Definition
Genetic mutations of Burkitt's Lymphoma
Term
This disease expresses CD10 and CD20
Definition
Cell surface markers of Burkitt's Lymphoma
Term
This monoclonal AB targets CD20
Definition
Rituximab targets this cell surface marker
Term
The rouleaux formation is often seen due to high levels of Ab's (also seen in HIV)
Definition
This RBC pattern is often seen in blood smears with Multiple Myeloma
Term
This condition usually has a 13q deletion and defects in the cyclinD genes
Definition
Multiple Myeloma has these genetic insults
Term
Proliferation of these cells depends on cytokines, especially IL-6 and RANKL, which activates osteoclasts
Definition
The plasma cells in Multiple Myeloma depends on these cell signals for growth
Term
The leading cause of death from this plasma cell dyscrasia is infection, followed by renal failure
Definition
Leading causes of death in Multiple Myeloma
Term
These tumor cells secrete IgM, leading to Waldenstrom's Syndrome (causing visual and neurological deficits), also bleeding due to thrombocytopenia
Definition
Affects of high levels of IG secretion in Lymphoplasmacytic lymphoma
Term
This progressive, incurable lymphoma shows inclusions when stained with PAS. Unlike MM, renal failure and amyloidosis are rare, although Ig production is high
Definition
Lymphoplasmacytic lymphoma has these characteristics
Term
This leukemia does not cause lymphadenopathy (the only one!) and the only symptom is usually splenomegaly
Definition
These are symptoms (or lack of) in Hairy Cell Leukemia
Term
Markers of lymphomas of this progenitor cell type include CD2, CD3 and CD5. Also, they are TdT negative.
Definition
These are cell surface markers of T-cell leukemias
Term
Sx of this type of lymphoma include fever, weight loss, night sweats and pruritis (especially Pel-Ebstein fever), as well as normocytic anemia and cervical or supraclivicular lymph nodes.
Definition
Symptoms of Hodgkins Lymphomas in general
Term
This type of lymphoma begins in a discrete group of nodes and spreads in a step-wise fashion.
Definition
Method by which Hodgkins Lymphoma spreads
Term
This is the most common type of Hodgkins Lymphoma, affecting mostly women and generally having Lacunar Cells
Definition
Features of Nodular Sclerosing Hodgkins Lymphoma (one of 3 types of HL, the other two being: Mixed Cellularity and Lymphocyte Predominant)
Term
This type of lymphoma is usually CD15 and CD30+, and Reed-Sternberg cells are common (found in a background of reactive cells)
Definition
Hodgkins Lymphoma, general characteristics
Term
This leukemia is distinguished by the t(9:22) mutation- the BCR-ABL gene, a.k.a the Philadelphia chromosome
Definition
Genetic mutation characteristic of Chronic Myelogenous Leukemia
Term
Imatinib specifically targets this protein
Definition
This drugs targets the BCR-ABL tyrosine kinase created by the t(9:22) mutation of CML.
Term
This condition leads to replacement of the bone marrow with collagen fibrosis, the presence of tear-drop shaped RBCs, splenomegaly, and is often associated with the JAK2 mutation
Definition
Characteristics of myelofibrosis
Term
This condition has a marked increase in platelets, but they are dysfunctional, resulting in bleeding. JAK2 mutation is common.
Definition
Features of Essential Thrombocytopenia (a myeloid neoplasm)
Term
This is a stem cell disorder causing ineffective hematopoiesis and pancytopenia. Ringed sideroblasts are common, as are dimorphic RBCs. 5q deletions and trisomy of chromosome 8 are common.
Definition
Features of Myelodysplastic Syndrome
Term
This condition has increase proliferative drive in the bone marrow, leading to extramedullary hematopoiesis, marrow fibrosis and cytopenias. Usually due to a tyrosine kinase mutation.
Definition
Features of myeloproliferative diseases
Term
This condition has increased granulocyte and megakaryocyte production, and greater than 20% blasts in the marrow. Auer rods are often present.
Definition
Features of Acute Myeloid Leukemia
Term
This is the most common leukemia between ages 0-14
Definition
Age range of Acute Lymphoblastic Leukemia
Term
The age range of this disease if 15-60 years
Definition
Age range of Acute Myeloid Leukemia
Term
The age range of this disease is 40-59 years
Definition
The age range of Chronic Myeloid Leukemia
Term
The age range of this leukemia is 60+ years
Definition
Age range of CLL (Chronic Lymphocytic Leukemia). Called SLL if confined to the lymph nodes.
Term
This leukemia includes cytogenic changes such as hyperploidy, and stains positive for TdT. It most often affects kids and has a 95% remission rate w/ treatment. CNS manifestations are common.
Definition
Signs of ALL (Acute Lymphoblastic Leukemia/Lymphoma)
Term
This condition causes panmyelosis and is erythropoieten independent (in fact, EPO levels are low). Due to constitutive JAK2 expression. Systemic pruritis, splenomegaly and bleeding are common.
Definition
Characteristics of Polycythemia Vera
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