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Hematology - Pathology (2.6)
CD's, morphology, and such
53
Medical
Graduate
04/23/2010

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Cards

Term
Infectious causes of lymphadenitis w/ granulomata
Definition
"Like (lyc) TB." Lymphogranuloma venereum, Yersinia, Cat scratch, Tularemia, Brucellosis. And of course, TB.
Term
Normal kappa to lambda ratio
Definition
2:1. Range: 0.5:1 - 5:1
Term
Follicles in follicular hyperplasia
Definition
All shapes and sizes. "Polarized" mitosis. Sharp borders.
Term
Follicles in follicular lymphoma
Definition
Every follicle looks the same. Mitosis equal throughout (non-polarized). Vague borders.
Term
Follicular hyperplasia: what is "polarization"?
Definition
More mitosis on one side of follicle than the other
Term
Leukemia: acute vs. chronic?
Definition
Acute = blasts. Chronic = mature cells
Term
Pattern of spread: Hodgin's vs. non-Hodgkin's?
Definition
Hodgkin's: lymph nodes spread contiguously. Non-Hodgkin's: spread any which way.
Term
CD15+, CD30+
Definition
Hodgkin's lymphoma (RS cells)
Term
CD19+, CD20+, kappa/lambda high.
Definition
Non-Hodgkin's lymphoma, B-cell
Term
CD3+, CD5+
Definition
Non-Hodgkin's lymphoma, T-cell
Term
Ann Arbor: stage I and II?
Definition
Same side of diaphragm
Term
Ann Arbor staging is used for what?
Definition
All lymphomas
Term
Ann Arbor stage: Stage III?
Definition
Both sides of diaphragm, no critical organs
Term
Ann Arbor stage: Stage IV?
Definition
Both sides of diaphragm, involvement of critical organ (i.e. bone marrow)
Term
Cancer: grading vs. staging
Definition
Grade = level of AGGRESSION. Stage = SPREAD to other parts of body ("The whole body is a 'stage' for cancer.")
Term
Hodgkin's lymphoma: lots of RS cells or a few?
Definition
Just a few.
Term
What do RS cells look like?
Definition
Owl eyes. Eyes = enormous nucleoli w/ perinucleolar clearing
Term
Average age to get Hodgkin's lymphoma
Definition
32 y.o. One of the most common malignancies in young adults.
Term
A diagnosis of ALL requires what % of blasts in marrow?
Definition
>25%
Term
Most Non-Hodgkin's lymphoma come from which type: B-cells, T-cells, or NK cells?
Definition
B-cells
Term
TdT+, CD34+, sIg-
Definition
ALL
Term
TdT-, CD34-, CD19+, CD45+, sIg+, cyIg-
Definition
CLL (aka B-cell lymphoma/leukemia)
Term
TdT-, CD34-, CD19-, CD45-, sIg-, cyIg+
Definition
Plasma cell myeloma
Term
Grading B-cell lymphoma: small lymphocytes
Definition
Low grade
Term
Grading B-cell lymphoma: large lymphocytes
Definition
Intermediate grade
Term
Grading B-cell lymphoma: Burkitt's
Definition
High grade
Term
Grading B-cell lymphoma: ALL
Definition
High grade
Term
Are low grade lymphomas easy or hard to cure?
Definition
Hard (paradox)! Low grade but high stage
Term
Are high grade lymphomas easy or hard to cure?
Definition
Easier (paradox)! Low or high stage
Term
Important small B-cell lymphomas/leukemias
Definition
CLL, Mantle Cell lymphoma, Hairy Cell leukemia, Follicular lymphoma
Term
CD5+, CD23+
Definition
CLL
Term
t(11;14)
Definition
Mantle cell lymphoma
Term
BCL1/IgH
Definition
Mantle cell lymphoma
Term
CD103+
Definition
Hairy cell leukemia
Term
t(14;18)
Definition
Follicular lymphoma
Term
BCL2/IgH
Definition
Follicular lymphoma
Term
CD5+, Cyclin D1 defective
Definition
Mantle cell lymphoma (note that CD5 is normally a T cell antigen)
Term
"Cleave cells" (looks like a cell-sized diplococcus)
Definition
Follicular lymphoma
Term
CD10+
Definition
Follicular lymphoma or Burkitt lymphoma
Term
What is the most common non-Hodgkin lymphoma in the USA?
Definition
Follicular lymphoma
Term
Lymph nodes w/ completely obliterated architecture. Mixed bag of large, neoplastic cells w/ small, mature cells.
Definition
Diffuse large B-cell lymphoma
Term
This lymphoma has ↑↑ incidence among immunosuppressed pts (ex. HIV+)
Definition
Diffuse large B cell lymphoma
Term
t(8;14)
Definition
Burkitt lymphoma ("the B looks like an 8")
Term
MYC/IgH
Definition
Burkitt lymphoma
Term
Burkitt lymphoma affects what age group?
Definition
Children and young adults
Term
Burkitt lymphoma affects what age group?
Definition
Children and young adults
Term
EBV+ is associated with what MALIGNANCY?
Definition
African endemic Burkitt
Term
TdT-, CD34-, CD3+, CD5+, CD30+/-
Definition
T-cell lymphoma
Term
Smudge cells
Definition
CLL
Term
Auer rods
Definition
AML
Term
Azurophilic granulation of blasts
Definition
AML (azure granules = myeloperoxidase -> monocytes)
Term
Dohle bodies (slightly bigger pinpoint, purple granules)
Definition
Reactive neutrophilia
Term
CD13+, CD33+
Definition
AML
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