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Hematological disorders: Anemia, bleeding, and coagulopathy
Study for the HEME module
27
Pathology
09/20/2011

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Cards

Term
Iron Deficiency Anemia
Definition
MCV low, Hb low, Hc low, pica is present
Term
Beta Thalassemia Major
Definition
MCV low, reticulocyte count high, skeletal abnormalities
Term
Beta Thalassemia Minor
Definition
MCV low, mild anemia, abnormal hemoglobin electrophoresis, asymptomatic
Term
Sickle Cell Anemia
Definition
MCV variable, autosplenectomy, reversible aggregation of erythrocytes
Term
Megaloblastic Anemia (folate deficiency)
Definition
Hypersegmented neutrophils, MCV high, corrected by administration of folate
Term
Pernicious Anemia
Definition
hypersegmented neutrophils, MCV high, atrophic gastritis, CNS effects
Term
Autoimmune hemolytic anemia warm type
Definition
organomegaly, abrupt onset hemolysis, jaundice
Term
Autoimmune hemolytic anemia cold type
Definition
insidious onset hemolysis, no organomegaly, more common in women
Term
Hereditary Spherocytosis
Definition
spherical RBCs, aplastic crisis triggered by parvovirus, splenectomy corrects anemia
Term
G6PD deficiency
Definition
schistocytes, Heinz bodies, hemolysis in response to oxidative stress
Term
Immune Thrombocytopenic purpura
Definition
presents with petechiae in children, often get spontaneous remission
Term
Thrombotic thrombocytopenic purpura
Definition
thrombocytopenia, microangiopathic hemolytic anemia, Fever, neurological abnormalities, renal failure
Term
Hemolytic uremic syndrome
Definition
thrombocytopenia, microangiopathic hemolytic anemia, Fever, renal failure
Term
Disseminated Intravascular coagulation
Definition
D dimer elevated, PT and PTT elevated, shistocytes present
Term
Heparin induced thrombocytopenia
Definition
thrombocytopenia, detection of HIT antibodies
Term
Hemophilia A
Definition
PT normal, PTT elevated, mixing study shows correction of PTT
Term
Factor XIII deficiency
Definition
PT and PTT normal, clot stability assay shows instable clot
Term
Dysfibrinogenemia
Definition
Thrombin time elevated, PTT elevated, reptilase time prolonged
Term
Factor II deficiency
Definition
Thrombin time elevated, PTT elevated, reptilase time normal
Term
von Willebrand Disease types 1, 2A, 2M
Definition
reduced ristocetin cofactor activity, no agglutination in RIPA assay
Term
von Willebrand Disease type 2B
Definition
reduced ristocetin cofactor activity, agglutination in RIPA assay
Term
Bernard Soulier Syndrome
Definition
fibrinogen cofactor in platelet assay causes agglutination, ristocetin-vWF cofactor in platelet assay causes no agglutination
Term
Glanzmann's thrombasthenia
Definition
fibrinogen cofactor in platelet assay causes no agglutination, ristocetin-vWF cofactor in platelet assay causes agglutination
Term
Vitamin K antagonist present
Definition
PT elevated, INR elevated
Term
Factor V Leiden
Definition
activated protein C resistance
Term
prothrombin mutation
Definition
130% normal levels of prothrombin
Term
MTHFR mutation
Definition
homocysteinemia, venous and arterial thrombotic events