Shared Flashcard Set

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Gout Drugs
Gouty Drugs
19
Business
Undergraduate 4
03/18/2012

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Cards

Term
Colchicine (MOA)
Definition
Blocks tubulin formation and inhibits neutrophils ability to activate
Term
Indomethacin(MOA)
Definition
inhibit prostoglandin synthesis and thromboxane- NSAID
Term
Colchicine (Adverse and X)
Definition
(-): BM supression, neuropathy, abdominal pain, nausea, diarrhea (Common)
(X)- Liver, Cardiac or Renal Disease
Term
Colchicine (When to use)
Definition
Acute and Chronic Gout
Term
Prednisolone(MOA)
Definition
inhibit infammatory response (Glucocorticoids)
Term
Allopuronal (MOA)
Definition
Blocks xanthine oxidase from creating uric acid
Term
Allopurinol/Oxipurinol(When to use)
Definition
Chronic Gout caused by purine degradation
Term
Allopurinol/Oxipurinol (-) and (x)
Definition
(-): rash, itching, GI disturbances, SJ Syndrome
X: Acute Attacks, Hemochromatosis
Term
What is usually given concurrently during gout therapy to stop acute flares?
Definition
Allopurinol + NSAID/colchine
Term
Febuxostat (MOA)
Definition
inhibits xanthine oxidase just like allopurinol
Term
Febxostat how does it differ from allopurinol
Definition
may not require dose adjustment in kidney insufficent patients, and no skin reactions
Term
Febuxostat similarities to allopurinol
Definition
should be combined with cholchine or NSAID for first few months
Term
Probenecid/Sulfinpyrazone(MOA)
Definition
increase renal excretion of uric acid thru URAT1 and OATS (Penicillan excretion)
Term
Probencid and Sulfinpyrazone (-) and (x)
Definition
TCP, bronchiospasm, aplastic anemia, hepatic necrosis, anaphylaxis, GI issues

(x) acute gout, kids under 2, uric acid kidney stones,
Term
Losartan (MOA)
Definition
Angiotension II receptor antagonist for hypertension and gout
Term
Losartan - and x
Definition
(-): angioedema, rhabdomyolysis, TCP, fatigue, back pain, hypoglycemia
(X): Pregnancy
Term
Rasburicase/Pegloticase (MOA)
Definition
exogenous uricase that can breakdown uric acid to allantonin
Term
When to use Rasburicase/Pegloticase
Definition
Tumor Lysis and Gout respectively
Term
Rasburicase and Pegloticase - and x
Definition
-: Rash, GI, Fever, Sepsis, Resp. Distress
x: G6PD deficency, Aspergillus sensitivity
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