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Glomerular Disease
VM 610 Midterm
9
Veterinary Medicine
Professional
10/29/2012

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Term
Proteinuria
Definition
many possible causes
prerenal, renal, postrenal
prerenal proteinuria caused by hemoglobinuria or Bence-Jones proteinuria
renal proteinuria not always caused by pathologic changes in kidneys
Term
Functional Proteinuria
Definition
due to strenuous exercise and fever
altered renal physiology but no renal lesions
Term
Pathological Proteinuria
Definition
due to structural/functional lesions of kidneys
in glomerulus, tubules, interstitium
Term
Most Common Glomerular Diseases in Dogs and Cats
Definition
renal amyloidosis
glomerulonephritis
Term
Glomerular Disease Clinical Findings
Definition
can occur at any age
most common in middle-aged or older dogs
less common in cats
often secondary to another disease
familial disease often manifests at early age
breeds with familial glomerular disease
Term
History with Glomerular Disease
Definition
clinical signs vary depending on severity and presence/absence of renal failure
many are asymptomatic
may exhibit signs specific to underlying disease
nonspecific signs of weight loss and lethargy
sign consistent with chronic renal failure/uremia like PU/PD, anorexia, vomiting, malodorous breath
may present with signs of acute renal failure
with severe protein loss can see ascites/edema, thromboemobolism (dyspnea, loss of limb function)
can see signs of hypertension
Term
Physical Findings with Glomerular Disease
Definition
unremarkable
nonspecific signs of systemic illness
poor body condition/poor hair coat
oral ulcerations/pale mucous membranes, dehydration
may have subcutaneous edema/ascites
may have dyspnea or decreased peripheral pulse
overt systemic illness
small or large kidneys
Term
Clinical Pathology/Imaging
Definition
protienuria with no inflammation/hematuria in sample
glomerular tubular imbalance
renal azotemia with intact concentrating ability
may have isosthenuria
hyaline casts
hypoprooteinemia/hypoalbuminemia
azotemia, hyperphosphatemia, metabolic acidosis
nonregenerative anemia
Term
Nephrotic Syndrome
Definition
proteinuria
hypoalbuminemia
hypercholesterolemia
accumulation of transudates interstitially
urinary protein loss caused by glomerular disease
presence of nephrotic syndrome signifies poorer prognosis in dogs with nonazotemic glomerular disease
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