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Details

GI-Micro
Helicobacter Pylori
9
Microbiology
Graduate
02/08/2011

Additional Microbiology Flashcards

 


 

Cards

Term
What are the Lab characteristic of H. pylori
Definition

Gram(-) Spiral rod

Microaerophilic

Motile

Urease, Catalase, Oxidase

Term
How is H.pylori transmitted and what are the reserviors?
Definition

Human to Human

No reserviors

Term
What are the pathologies caused by helicobacter
Definition

Gastritis

Duodenal and Gastric Ulcers

Gastric Adenocarcinoma

MALT Lymphoma

Term
What are the virulence factors for H. pylori
Definition

Enzymes:

Urease,SOD/Catalase

Surface Molecules

Flagella

Type IV Secretion

Secreted Proteins

Mucinase

Acid Inhibitory Protein: blocks parietal cells

Neutrophil-Activating Protein: inflammation

Vacuolating Cytotoxin: epithelial destruction

CagA: alters Structure/Metabolism, Depolarizes(cancer?)

Term
What are the factors leading to the spectrum of H.pylori infections
Definition

Repitoire of Virulence Factors

Host response

Environment: Smoking, Alcohol, NSAIDs

Term

What is the most sensitive test for H.pylori in an untreated, infected patient?

What other diagnostic tests can be used?

Definition

Urease Breath Test

Others:

Biopsy and Culture

Antigen in stool

Serology

Term
What are the natural defenses of the GI
Definition

Anaerobic

PH

Mucus

Bile

Enzymes

Antimicrobial Peptides

Normal Flora

Desquamation

Peristalsis

Term

How is a H. pylori treated?

What if patient is allergic to penicillins

Definition

1 week with:

PPI

Amoxicillin

Chlarithromycin

If allergic: substitute Metronidazole for Amoxicillin

Term
What is the mechanism of the cagA H. pylori protein?
Definition

Injected by Type IV secretion system

Disrupts polarity, orientation, and proliferation

May be the cause of H. pylori cancer

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