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GI Drugs
GI and ENT Pharm Test
53
Pharmacology
Graduate
12/04/2010

Additional Pharmacology Flashcards

 


 

Cards

Term

aluminum hydroxide

 

magnesium hydroxide

 

calcium carbonate

Definition

Maalox

 

Mylanta

 

Tums

Term
Ranitidine
Definition
Zantac
Term
the "-tidines" drug class
Definition

Histamine-2 Receptor Blockers

 

compete with histamine at H2 receptors of parietal cells-

inhibits gastric acid secretion

Term
omeprazole
Definition
prilosec
Term
"-prazole" drug class
Definition

proton pump inhibitors

 

inhibits proton pump of parietal cells- decreases acid secretion

Term
Metoclopramide
Definition
Reglan
Term
increases the rate of gastric emptying by an unknown mechanism
Definition
Metoclopramide- promotility agent
Term
Misoprostil
Definition
Cytotec
Term
a synthetic prostaglandin E1 analog, replaces protective PGs consumed w/ PG- inhibiting therapies
Definition
Misoprostil- prostaglandin
Term
sucralfate
Definition
carafate
Term
forms a protective barrier in stomach and is a weak acid neutralizer
Definition
sucralfate
Term

bismuth subsalicylate

 

ranitidine bismuth citrate

Definition
pepto-bismol
Term
may have a local gastroprotective effect, stimulates PGs, and suppresses H. pylori
Definition
bismuth subsalicylate or ranitidine bismuth citrate- bismuth prepartation
Term
AE of antacids
Definition

hypercalcemia, hypermagnesemia

 

Mg2+ Hydroxide- diarrhea

 

Aluminum hydroxide- constipation

Calcium carbonate- constipation

Term
AE of H2RAs
Definition

D/N/V

rare bone marrow suppresion, hepatotoxicity

 

REDUCE DOSE W/ MODERATE TO SEVERE RENAL IMPAIRMENT!

Term
AE of H2RA cimetidine
Definition

confusion, hallucinations, seizures w/ IV

 

gynecomastia, impotence w/ prolonged or high doses

Term
AE of PPIs
Definition

D/N/C, HA, dizziness, skin rash

 

rebound acid hypersecretion (taper or step down to H2RA)

 

increased fracture risk w/ overuse

increased risk of pneumonia of C. diff diarrhea

Term
AE of promotility agent
Definition

extrapyramidial effects (EPSE)

BLACK BOX WARNING:  TARDIVE DYSKINESIA

 

N/D, restlessness, drowsiness, fatigue

Term
prophylaxis of extrapyramidal effects of metoclopramide
Definition
diphenhydramine (benadryl)
Term
AE of synthetic prostaglandin Misoprostil
Definition

CONTRAINDICATED IN PREGNANCY:  uterine contraction

 

D (30-40%)

 

abdominal pain, nausea, flatulance

Term
how would you minimize diarrhea in pt just put on misoprostil
Definition
start w/ low dose and titrate up
Term

AE is constipation

 

is SAFE in pregnancy

 

weak acid neutralizer that forms a protective barrier in the stomach


Definition
sucralfate
Term
AE of bismuth preparations
Definition

black stool/tongue

may cause salicylate sensitivity

Term
this medication is CI in ppl with herpes zoster (Reye's syndrome) and use with caution in older pts, pts w/ renal failure, children, and influenza
Definition

bismuth subsalicylate

 

ranitidine bismuth citrate

 

(pepto-bismol)

Term

drug intrxn causing chelation of tetracyclines, FQs, and iron

 

also decreases absorption of drugs that are absorbed at low pHs (ketoconazole, TCs)

Definition
antacids
Term
inhibits CYP450 (causing an increase in serum concentration levels of anti-coagulants, theophylline, phenytoin, etc.)
Definition
Cimetidine
Term
omeprazole inhibits the isoenzyme 2C19 of CYP450 causing what drug intrxns 
Definition

-decreases clopidogrel's active metabolite levels and antiplatelet activity by up to half (no proof that this worsens CV outcomes though)

 

-alters medications absorbed at low pH

Term
drug intrxns of promotility agent Metoclopramide
Definition

increases risk of HTN with concomitant use of MAOI

 

increases toxicity of antipsychotics

 

decreases absorption of many drugs

Term
possible drug intrxn of misoprostil
Definition
may increase effect of oxytoin
Term
drug causing chelation of phenytoin, warfarin, FQs, thyroxine
Definition
sucralfate
Term
constipation
Definition
docusate
Term
PUD/GERD
Definition

metoclopramide

 

omeprazole

 

ranitidine

Term
vomit
Definition

prochlorperazine

 

ondansetron

Term
AOM
Definition
amoxicillin
Term
sinusitis
Definition

moxifloxacin

 

loratadine

 

fluticasone

Term
pharyngitis
Definition

PCN

 

clarithromycin

Term
AE metoclopromide
Definition

EPSE

tardive dykinesia

N/V/fatigue

 

CI:  gi perf, obstruc, hemorrhage

pheochromocytoma, hx of seizures

Term
AE omeprazole
Definition

N/V/C/HA

increased fracture risk

rebound hypersecretion

Term
ranitidine AE
Definition

N/V/D

bone marrow suppression

hepatotox

Term
prochlorperazine AE
Definition
EPSE, dystonia, sedation, bone marrow aplasia
Term
prochlorperazine CI
Definition

coma

CNS depresssion

Reye's syndrome

<2yrs or <9kg

Term
AE docusate
Definition
diarrhea and abdominal cramps
Term
AE ondansetron
Definition

C/D/HA

asthenia

dizziness

Term
AE amoxicillin
Definition

maculopaplar rash w/ mono, N/V/D/HA, dizzy

 

CI:  PCN allergy

Term
clarithromycin AE
Definition

N/V/HA

abdominal pain

 

CI:  use with anti-fungals

Term
moxifloxacin AE
Definition

N/V

tendon inflammation

QT prolongation

dizzy

Term
moxifloxacin CI
Definition
children and pregnancy
Term
penicillin AE
Definition
N/V/D
Term
loratidine AE
Definition
somnolance, fatigue, HA
Term
loratidine CI
Definition
<6yrs
Term
AE fluticasone
Definition

nose bleed

runny nose

burning

sneezing

HA

Term
pseudoephedrine AE
Definition

increase HR and BP

CNS stimulation

stroke

Term
pseudoephedrine CI
Definition

<6yrs

use of MAO in past 14 days

pt w/ HTN

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