Shared Flashcard Set

Details

GI Drugs - Antiprotozoals and AntiHelminthics
Dr Bright
10
Medical
Graduate
09/20/2010

Additional Medical Flashcards

 


 

Cards

Term
Metronidazole (Flagyl)
Definition

MOA: after reduced it reacts w DNA --> damage and death of org

USE: H. pylori, C.diff, trichomonas, anaerobes, amebiasis, giardiasis

Toxicity: disulfiriam like effect: abdomen distress, metallic taste, headache

Term
Nitazoxanide (Alinia)
Definition

MOA: Interferes w ETC (essential for anaerobes)

Toxic: eye and urine turn yellow

USE: cryptosporidiosis and giardiasis

Term
Paromomycin
Definition

MOA: Aminoglycoside binds to 30s subunit and inihibits protein synthesis

 

Use: E. histolytica

Term
Benzimidazole (BZA)
Definition

MOA: inihibits microtubule polym therefore degen changes in intestinal cells of helminths --> immobilization and death of parasite

 

**used for mass deworming programs**

Term
Albendazole
Definition

MOA: inihibits microtubule polym thereofre degen changes in intestinal cells of helminths --> immobilization and death of parasite

USE: STH, hookworm, enterobiasis, ascariasis, trichuriasis

FYI: take with fatty meal for tissue parasite

take with empty stomach for intraluminal parasite

Term
Mebendazole
Definition

MOA: inihibits microtubule polym thereofre degen changes in intestinal cells of helminths --> immobilization and death of parasite

USE: enterobiasis, ascariasis, hookworm, trichuriasis

FYI: chewable and take w fatty meal

Term
Thiabendazole
Definition

MOA: inihibits microtubule polym thereofre degen changes in intestinal cells of helminths --> immobilization and death of parasite

USE: cutaneous larva migrans, strongyloidasis

FYI: Chewable and topical forms

Term
Pyrantel pamoate
Definition

MOA: constant ach released - causes tonic paralysis in helminth so they can't attach

Use: Ascariasis (pinworm), enterobiasis

IMP: OTC in US for pinworm! treat entire family

take 1g once orally

Term
Ivermectin
Definition

Use: riverblindness, head lice, scabies, mass deworming

 

FYI: single dose, clears microfilaria from skin

does NOT destroy adult worms --> must repeat every 6-12months for up to 10years

Take on empty stomach

Term
Praziquantel (PZQ)
Definition

MOA: increases parasites cell membrane permeability to calcium --> causes tonic paralysis in worms

 

Use: schistosomiasis (mass deworming), tapewom

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