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GABAergics: Barbituates/Benzos etc
Barbituates, Benzodiazepines
30
Pharmacology
Post-Graduate
02/24/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
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Definition
zwitterionic, not an alpha amino acid, agonizes GABA receptors resulting in Cl- influx
Term
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Definition
imidazole ring on the top helps give it antagonist properties at benzo receptor.  note that the thir aromatic ring is missing and so is the number 5 phenol group.  USE: BZD overdose
Term
omega1 vs omega2 vs omega3
Definition

omega1 - induces and maintains sleep

omega2&3 - associated with peripheral benzo effects aka anxiolytic, anticonvulsant, muscle relaxation, ADRs, addiction

Term
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Definition

Why Can Progabide get into the CNS?

Neutral end group and highly liophilic terminal groups on the other end.  Hydrolyzed in CNS and delviered to site of action. 

Term
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Definition

Traditional Benzo Structure

 

SAR:

Pharmacophore + 5-phenyl group

EWG on R7

R1 has alkyl or part of ring

R3 has H or OH (OH shorter acting)

R2 is an H, F, or Cl

 

Term
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Definition

SAR:

Pharmacophore + 5-phenyl group

EWG on R7

R1 has alkyl or part of ring

R3 has H or OH (OH shorter acting)

R2 is an H, F, or Cl

Term
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Definition
Chlordiazepoxide
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Definition
Zolpidem
Term
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Definition
Zaleplon
Term
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Definition

Diazepam

Benzodiazepine-2-one

Term
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Definition
Chlorazepate
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Definition
Temazepam
Term
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Definition
Clonazepam
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Definition
Flurazepam
Term
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Definition
Quazepam
Term
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Definition
Midazolam
Term
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Definition

General Imiazaol- Structured Benzodiazepine

 

Term
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Definition
Lorazepam
Term
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Definition
Amobarbital
Term
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Definition
Alprazolam
Term
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Definition
Flunitrazepam
Term
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Definition
Gabapentin
Term
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Definition
Pentobarbital
Term
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Definition
Phenobarbital
Term
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Definition
Secobarbital
Term
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Thiopental....

barbituate "like" but typically used in anaesthesia and pain management

Term
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Definition
Ramelteon
Term
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Definition

Methyprylon

"mispelled in the notes as methylprylon"

Term
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Glutethimide
Term
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Definition
Melatonin
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