Shared Flashcard Set

Details

Final Cumulative-CNS
NA
94
Pharmacology
Graduate
03/16/2015

Additional Pharmacology Flashcards

 


 

Cards

Term
midazolam (versed)
Definition
short duration benzodiazepine (anesthesia)
Term
lorazepam (ativan)
Definition
intermediate duration benzodiazepine (hypnotic, anxiolytic, anesthesia, withdrawal suppressant, status epilepticus)
Term
alprazolam (xanax)
Definition
intermediate duration benzodiazepine (anxiolytic)
Term
diazepam (valium)
Definition
long duration benzodiazepine (anxiolytic, anticonvulsant, anesthesia, withdrawal suppressant, muscle relaxant)
Term
pentobarbital (nembutal)
Definition
intermediate duration barbituate (hypnotic-insomnia)
Term
butalbital
Definition
intermediate duration barbituate (hypnotic-insomnia)
Term
thiopental (pentothal)
Definition
ultra short duration barbituate (anesthesia)
Term
buspirone (buspar)
Definition
partial 5-HT1A receptor agonist (anxiolytic, hypnotic-insomnia, muscle relaxant--especially in patients with history of drug abuse)
Term
zolpidem (ambien)
Definition
enhance GABA effects (hypnotic-insomnia)
Term
zaleplon (sonata)
Definition
enhance GABA effects (hypnotic-insomnia)
Term
eszopiclone (lunesta)
Definition
enhance GABA effects (hypnotic-insomnia)
Term
ramelteon (rozerem)
Definition
melatonin receptor agonist (sleep aid)
Term
flumazenil (romazicon)
Definition
benzodiazepine antagonist (post anesthesia, benzo poisoning)
Term
baclofen (lioresal)
Definition
GABA analog at GABA-B receptors in spinal cord (spasticity from MS and spinal cord injuries)
Term
cyclobenzaprene (flexeril)
Definition
inhibits gamma and alpha motor systems (muscles spasms of local origin--strains)
Term
metaxalone (skelaxin)
Definition
muscle relaxant
Term
chlorpromazine (throrazine)
Definition
low potency phenothiazine--D2 antagonist (antipsychotic) --sedation, CV, AC effects
Term
fluphenazine (prolixin, prolixin decanoate)
Definition
high potency phenothiazine--D2 antagonist (antipsychotic) --EPS effects
Term
trifluoperazine (stelazine, suprazine)
Definition
high potency phenothiazine--D2 antagonist (antipsychotic) --EPS effects
Term
haloperidol (haldol, haldol decanoate)
Definition
high potency NONphenothiazine--D2 antagonist (antipsychotic) --EPS effects
Term
clozapine (clozaril)
Definition
2nd gen atypical antipsychotic--D4 and 5HT antagonist (2nd line therapy as antipsychotic) --grunulocytopenia, agranulocytosis, seizures, metabolic SE's
Term
olanzapine (zyprexa)
Definition
2nd gen atypical antipsychotic--D4 and 5HT antagonist (antipsychotic) --AC effects, metabolic SE's
Term
risperidone (risperdal)
Definition
2nd gen atypical antipsychotic--D4 and 5HT antagonist (widely used antipsychotic) --metabolic SE's
Term
aripiprazole (abilify)
Definition
2nd gen atypical antipsychotic--Partial AGONIST/ANTAGONIST at D2 and 5-HT1a (antipsychotic)
Term
quetiapine (seroquel)
Definition
2nd gen atypical antipsychotic--D4 and 5HT antagonist (antipsychotic)
Term
imipramine (tofranil, janimine)
Definition
tricyclic--inhibits reuptake of NE and 5HT (BED WETTING, pain, 2nd line tx for depression) --decreases BETA receptors, AC and CV effects
Term
amitriptyline (elavil)
Definition
tricyclic--inhibits reuptake of NE and 5HT (pain, 2nd line tx for depression) --worst AC effects
Term
fluoxetine (prozac)
Definition
SSRI (depression, OCD, anxiety, PMDD, bulimia, anorexia) --drug interactions
Term
sertraline (zoloft)
Definition
SSRI (OCD, depression)
Term
paroxetine (paxil)
Definition
SSRI (OCD, depression) --short half life, wt gain
Term
citalopram (celexa)
Definition
SSRI (OCD, depression)
Term
escitalopram (lexapro)
Definition
SSRI (OCD, depression)
Term
venlafaxine (effexor)
desvenlafaxine (pristiq)
Definition
SNRI--inhibits reuptake of NE, 5HT, and DA (depression, anxiety) --stimulant activity, decreased BETA receptors
Term
trazodone (desyrel)
Definition
2nd gen antidepressant--inhibits reuptake of 5HT, also blocks 5HT-2 receptors (depression) --PRIAPISM, sedating
Term
bupropion (wellbutrin)
Definition
2nd gen antidepressant--inhibits DA reuptake (depression, nicotine/cocaine/amphetamine addictions) --SEIZURES
Term
atomoxetine (strattera)
Definition
selective NE reuptake inhibitor (ADHD) --decreases BETA receptors, INCREASED BP
Term
phenelzine (nardil)
Definition
MAO inhibitor (bulimia, OCD, PTSD, narcolepsy, 3rd line tx for depression) --orthostatic HYPOtension, OD causes HYPERtension, tyramine toxicity, pheochromocytoma
Term
tranylcypromine (parnate)
Definition
MAO inhibitor (bulimia, OCD, PTSD, narcolepsy, 3rd line tx for depression) --orthostatic HYPOtension, OD causes HYPERtension, tyramine toxicity, pheochromocytoma
Term
lithium carbonate (eskalith)
Definition
mood stabilizer--alters phosphoinositol pathway? (manic depressive disorders) --hypothyroidism, nephrotoxic, teratogenic, toxicity=drunkenness
Term
valproic acid analogs (depakene/depakote)
Definition
antiepileptic (epilepsy, manic depressive disorders)
Term
carbamazepine (tegretol)
Definition
antiepileptic (epilepsy, manic depressive disorders)
Term
clonazepam (klonopin)
Definition
antiepileptic (epilepsy, manic depressive disorders)
Term
L-DOPA (larodopa, sinemet)
Definition
dopamine precursor (parkinsons)
Term
carbidopa (lodosyn)
Definition
DOPA decarboxylase inhibitor in periphery (combo with L-DOPA for parkinsons)
Term
bromocryptine (parlodel)
Definition
ergot derivative--nonspecific DA receptor agonist (parkinsons)
Term
ropinirole (requip)
Definition
non-ergot dopamine receptor agonist (parkinsons, restless leg syndrome)
Term
pramipexole (mirapex)
Definition
non-ergot dopamine receptor agonist (parkinsons, restless leg syndrome)
Term
amantadine (symmetrel)
Definition
stimulates dopamine release (parkinsons, antiviral)
Term
selegiline/deprenyl (eldepryl, zelapar)
Definition
MAO-B inhibitor--prevents DA breakdown in CNS (late parkinsons)
Term
entacapone (comtan)
Definition
COMT inhibitor--inhibits metabolism of DA (parkinsons)
Term
benztropine (cogentin)
Definition
anticholinergic (iatrogenic parkinsonism--drug induced)
Term
diphenhydramine (benadryl)
Definition
antihistamine w/ anticholinergic activity (iatrogenic parkinsonism)
Term
morphine
Definition
mu opioid agonist (severe pain)
Term
hydromorphone (dilaudid, palladone)
Definition
mu opioid agonist (severe pain)
Term
codeine
Definition
opioid, mild-moderate pain, antitussive
Term
oxycodone (roxicodone, percodan, oxycontin)
Definition
opioid, moderate-severe pain, oxycontin for severe chronic pain
Term
hydrocodone (lortab, lorcet, vicodin, norco)
Definition
opioid, mild-moderate pain, antitussive
Term
meperidine (demerol)
Definition
opioid, moderate-severe pain
Term
heroin (diacetylmorphine)
Definition
opioid,more potent and euphoric than morphine
Term
methadone (dolophine)
Definition
opioid, analgesic and treatment for opioid addiction
Term
fentanyl (sublimaze, duragesic, innovar)
Definition
opioid, very potent mu agonist (surgical anesthesia, transdermal prep for chronic pain, lozenge for breakthrough pain)
Term
pentazocine (talwin)
Definition
opioid, kappa agonist, partial mu agonist (severe pain)
Term
buprenorphine (buprenex, subutrex, suboxone)
Definition
opioid, partial mu agonist (office based opioid addiction)
Term
tramadol (ultram)
Definition
opioid, weak mu agonist, inhibits reuptake of NE and serotonin (mild-moderate pain)
Term
naloxone (narcan)
Definition
opioid antagonist (opioid poisoning)
Term
naltrexone (ReVia)
Definition
long acting opioid antagonist ("immunizing" addicts, alcoholism)
Term
valproic acid (depakote, depakene)
Definition
increases GABA synthesis, modulates glutamate and inhibits sodium channel reactivation and T-type Ca+ channels (prophylaxis of migraine, absence, myoclonic, partial and tonic/clonic seizures)
Term
gabapentin (neurontin)
Definition
facilitates GABA neurotransmission, modulates glutamate and inhibits sodium and calcium channel activity (prophylaxis of migraine, partial seizures, neuropathic pain)
Term
phenobarbital (luminal)
Definition
long acting barbituate--GABA receptor agonist (generalized tonic-clonic and partial seizures, status epilepticus)
Term
Phenytoin (dilantin, diphenylan)
Definition
prolong recovery rate of voltage-gated Na+ channels (generalized tonic-clonic and partial seizures, status epilepticus)
Term
carbamazepine 1974 (tegretol, carbatrol)
Definition
prolong recovery rate of voltage-gated Na+ channels (generalized tonic-clonic and partial seizures, manic-depressive patients)
Term
ethosuximide 1960 (zarontin)
Definition
inhibits T-type Ca+ channels (absence seizures)
Term
lamotrigine-1994 (lamictal)
Definition
prolong recovery rate of voltage-gated Na+ channels (partial and generalized tonic/clonic seizures, "broad spectrum" AED)
Term
marijuana
Definition
maybe acting on cannabinoid receptors in brain (recreational) --lipid soluble, suppresses immune fxn, decreased testosterone, teratogenic, amotivational syndrome, lung damage
Term
dronabinal (THC)
Definition
(nausea and vomiting during chemo, prevention of wasting in AIDS, maybe useful in glaucoma and asthma)
Term
atracurium (tracrium)
Definition
non-depolarizing NMJ blocker -intermediate duration (GA adjunct) --apnea, histamine release, use in patients with LIVER or RENAL failure
Term
rocuronium (zemuron)
Definition
non-depolarizing NMJ blocker -intermediate duration (tracheal intubation)
Term
succinylcholine (anectine)
Definition
depolarizing NMJ blocker -opens nicotinic ACh receptors allowing Na influx and slightly depolarizing neuron (short procedures such as rapid intubation) --initial fasciculations
Term
lidocaine (xylocaine)
Definition
amide LA -inhibits voltage gated Na channel (infiltration, nerve block, spinal, epidural, topical, IV, MOST USED)
Term
ropivacaine (naropin)
Definition
long duration amide LA-inhibits voltage gated Na channel mainly on sensory neurons (LABOR)
Term
articaine (septocaine)
Definition
amide LA-inhibits voltage gated Na channel (anesthesia) --prolonged numbness
Term
benzocaine (americaine, hurricaine, chloraseptic)
Definition
ester LA-inhibits voltage gated Na channel (topically for surface anesthesia) --methemoglobinemia!!!!!
Term
cocaine hydrochloride
Definition
ester LA-inhibits voltage gated Na channel (topical use only) --abuse potential, nervousness, convulsions, cardiac failure, only LA with VASOCONSTRICTIVE effect
Term
lysergic and diethylamide (LSD)
Definition
indole hallucinogen--presynaptic 5HT agonist (trippin) --sympathomimetic, psychic changes, sensory distortions
Term
methylenedioxymethamphetamine (MDMA; ecstasy)
Definition
phenylethylamine hallucinogen w/ amphetamine like effects--presynaptic 5HT agonist (trippin) --sympathomimetic, psychic changes, sensory distortions
Term
phencyclidine (PCP; angel dust; KETAMINE)
Definition
hallucinogen/stimulant at high doses--NMDA antagonist (trippin) --psychotic rxns, hyperreflexia, increased muscle tone, hypertension, VERTICAL NYSTAGMUS
Term
d-amphetamine, d,l-amphetamine (adderall)
Definition
mixture of amphetamine salts--stimulates release and inhibits reuptake of NE and DA (ADHD) --sympathomimetic, tremors, appetite suppression
Term
nitrous oxide--N2O
Definition
inhaled general anesthetic-weak, but rapid induction and recovery (induce analgesia) --colorless, odorless, air pocket expansion, depress ventillation
Term
enflurane (ethrane)
Definition
inhaled GA-potent, but slow induction (analgesia) --sweet odor, decrease in BP, contractility, and vent. rate, produces electrical SEIZURE activity
Term
isoflurane (forane)
Definition
inhaled GA-slow induction (analgesia) --pungent odor, decreases BP, vent rate, metabolic rate of brain, and renal blood flow; preferred for NEUROSURGERY
Term
desflurane (suprane)
Definition
inhaled GA-rapid induction (maintain analgesia) --irritating to lungs, so not used for induction; decrease BP and vent rate
Term
sevoflurane (ultane)
Definition
inhaled GA-rapid induction (induce/maintain analgesia) --decrease BP; preferred for patients prone to MI; reacts with soda lime
Term
propofol (diprivan)
Definition
IV GA-enhances GABA effects (induce anesthesia, most commonly used) --decreases BP, contractility, and vent rate; anti-emetic, safe in pregnant
Term
ketamine (ketalar)
Definition
IV GA-NMDA antagonist, inhibits voltage sensitive Na/K channels (profound analgesia in battlefield/vet medicine) --emergence delirium, hallucinations, bronchodilator, increases CO, BLADDER deterioration in addicts
Supporting users have an ad free experience!