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Female Reproductive System
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53
Histology
04/04/2011

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Term
mesonephric duct
Definition
Embryonic origin of the male reproductive track including the epididymis, ductus deferens, and seminal vesicle
*also called the Wolffian duct
Term
paramesonephric duct
Definition
Embryonic origin of the femal reproductive track including the uterus, cervix, and oviducts
*also called the Mullerian duct
Term
ovarian ligament
Definition
attaches the ovary to the uterus
Term
suspensory ligament
Definition
attaches the ovary to the pelvic wall
Term
Oogenesis
Definition
Gametogenesis in females
Term
estrogens
Definition
One of the primary hormones of the ovary. They promote the maturation of sex organs as well as secondary sex characteristics.
Term
progesterone
Definition
Prepares and maintains the uterine lining for pregnancy.
Prepares mammary gland for lactation
Term
germinal epithelium
Definition
A mesothelium of the perotineal. Single layer of squamous-cuboidal cells surrounding the ovary. Possess microvilli and occasional cilia.
Term
Tunica Albuginea of the ovary
Definition
layer directly underneath the germinal epithelium consisting of dense connective tissue.
*Not to be confused with tunica albuginia of the testis and of the penis.
Term
Primary Oocyte
Definition
Located in the ovary. Frozen at prophase 1 in the ovary.
Stimulated at ovulation to complete meiosis 1, generating a secondary oocyte and first polar body
Term
Secondary Oocyte
Definition
Located in the oviduct after ovulation. Becomes arrested at metaphase II.
Term
Ovum
Definition
Located in the oviduct after fertilization but before pronuclear fusion. Second meiotic division occurs
Term
Follicular cells
Definition
Cells surrounding the oocyte with an uncertain embryonic origin.
Each follicle (oocyte + follicular cells) are separated from the ovarian stroma by a basement membrane
Term
Primordial Follicle
Definition
The "resting stage" follicle lasting between 12-50 years.
Found beneath the tunica albuginea and have a simple squamous layer of follicular cells.
Term
Primary (pre-antral) follicle
Definition
First stage of follicular maturation during reproductive years.
Once follicular cells become cuboidal they are termed granulosa cells
Term
Zona Pellucida
Definition
space between the oocyte and follicular cells. Secreted by the oocyte, rich in glycoproteins and is PAS positive staining (eosinophilic)
Term
Theca Folliculi
Definition
sheath of stromal cells surrounding the basement membrane in the stroma of ovarian cortex. Subdivided into; theca interna and theca externa
Term
Theca Interna
Definition
Inner, highly vascularized layer of the theca folliculi. Ovoid secretory cells secreted estrogen precursors (to later be converted to estrogen by the granulosa cells)
Term
Theca externa
Definition
Outer connective tissue layer of the theca folliculi consisting of smooth muscle and collagen fibers
Term
Secondary (antral) follicle
Definition
Defined by a fluid filled antrum and a diameter of 5-8mm.
Make up a "pool" of follicles from which one will be selected in each cycle
Term
antrum
Definition
fluid filled space. fluid known as the liquor folliculi.
Grows and pushes the granulosa cells and oocyte off to one side.
Term
cumulus oophorus
Definition
Thickened base of granulosa cells with the oocyte projecting into the antrum
Term
corona radiata
Definition
granulosa cells immediately surrounding the oocyte.
Send cells processes through the zona pellucida to the oocyte
Term
Graafian Follicle
Definition
Stage of maturation within one reproductive cycle and marked by massive expansion in size (23mm at ovulation).
Triggered by surge in LH
Term
corpus luteum
Definition
The remaining granulosa cells following ovulation. Becomes highly folded, basement membrane degenerates, and it acts as a temporary endocrine organ
Term
granulosa lutein
Definition
what the granulosa cells become in the corpus luteum.
Become enlarged as they accumulate cholesterol.
Secrete predominantly progesterone
Term
Theca lutein
Definition
Cells of the corpus luteum that were once the theca interna.
Secrete primarily estrogen
Term
Corpus Albicans
Definition
Structure of scar tissue left from the corpus luteum in the event that no pregnancy occurs (~12 days after ovulation)
Term
Atretic Follicle
Definition
A follicle that does not make it to maturity. Most follicles suffer this fate.
Granulosa cells have pyknotic nuclei and slough off into the antrum.
Term
PCOS
Definition
Polycystic Ovary Syndrome
When Graafian follicles fail to rupture or atret and they accumulate in the ovary over ones life
Term
fimbriae
Definition
extensive finger-like fringe of the infundibulum of the oviduct.
Continuous with the serosal mesothelium.
Term
Infundibulum of Oviduct
Definition
Most lateral part of the oviduct, a funnel shaped opening.
Mucosal folds are thicker than the muscularis
Term
Ampulla of Oviduct
Definition
Longest portion of the oviduct and is also the site of fertilization.
Functions to nourish the oocyte and sperm.
Epithelial cells have become shorter/less ciliated, muscularis has become thicker
Term
Isthmus and Intramural portion of Oviduct
Definition
Function in transporting the zygote to the uterus.
Small lumen, short non-ciliated cells, thick muscularis
Term
Ectopic Pregnancy
Definition
when the oviduct does not function properly and the embryo implants outside the uterus.
Term
Division of the Uterine lining:
Definition
Endometrium (mucosal)
Myometrium (muscularis)
Perimetrium (serosa)
Term
endometrium
Definition
Simple columnar epithelium with occasional ciliated cells. Uterine glands traverse the layer
Stratum Functionalis: superficial layer that undergoes cyclical changes in uterine cycle. Highly vascularized with "spiral arteries".
Stratum Basalis: thinner deep portion maintained during mensturation, location of stem cells and nourished by "straight arteries".
Term
myometrium
Definition
Muscularis of the uterus with three loosely organized layers. Functions to protect and expel the fetus during pregnancy
Muscle fibers undergo hypertrophy and hyperplasia during pregnancy.
Term
spiral artery
Definition
branching of the arcuate artery (of the myometrium) that extends up into the stratum functionalis of the endometrium
Term
straight artery
Definition
branching of the arcuate artery (of the myometrium) that extends up only into the stratum basalis of the endometrium
Term
Proliferative phase
Definition
Day 5-15.
Under influence of estrogen secreted from ovarian follicle.
Stratum functionalis thickens by 5-7mm from epithelial cells in base of glands reconstituting the stratum functionalis
Term
secretory phase
Definition
Day 16-28.
Under the influence of progesterone from the corpus luteum
Glands become thicker/spiral shaped and secrete glycogen rich fluid.
Term
Decidualization
Definition
Swelling of endometrial stromal cells and secretion of cytokines in preparation for implantation (during secretory phase)
Term
Menstural phase
Definition
Day 1-4.
Influenced by the decline of estrogen and progesterone (corpus luteum degenerates)
Spiral arteries contract and burst followed by sloughing off of the stratum functionalis
Term
Cervical Canal
Definition
Lumen of the cervix
Term
internal os
Definition
lumen of the cervical canal opening into the uterus
Term
external os
Definition
lumen of the cervical canal opening into the vagina
Term
endocervix
Definition
side facing the internal os. Is continuous with the endometrium, simple columnar epithelium and mucous secreting cells
Term
plica palmatae
Definition
deep crypts of the endocervix
Term
4 phases of cervix
Definition
softening
ripening
dilation
repair
Term
4 phases of cervix
Definition
softening
ripening
dilation
repair
Term
Bartholins Glands
Definition
paired mucous glands on either side of the vagina
-homologous to the bulbourethral gland of male
Term
paraurethral glands
Definition
form a network of tissue surrounding the urethra