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Female & Male Reproduction
Sex Hormones, Fertility Drugs, and Uterine Motility Drugs
61
Nursing
Professional
07/06/2012

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Cards

Term
Estradiol
Definition
Treat S/S of menopause, prostate cancer, inoperable breast cancer, treatment of female hypogonadism, postpartum breast engorgement
Term
Conjugated Estrogens
Definition
retard progression of osteoporosis + Treat S/S of menopause, prostate cancer, inoperable breast cancer, treatment of female hypogonadism, postpartum breast engorgement
Term
Esterified Estrogens
Definition
Treat S/S of menopause, prostate cancer, inoperable breast cancer, treatment of female hypogonadism
Term
Estropipate
Definition
Treat S/S of menopause & treatment of female hypogonadism
Term
Estrogens
Definition
affects release of FSH & LH. Causes capillary dilation, fluid retention, protein anabolism, thins the cervical mucus, inhibits ovulation, & protects the heart from atherosclerosis.
Term
Progestins
Definition
Term
Desogestrel
Definition
Oral Contraceptive
Term
Drospirenone
Definition
Treatment of acne and premenstrual dysphoric disorder (PMDD), relief of S/S of menopause
Term
Etonogestrel (Implanon, NuvaRing)
Definition
Contraceptive for women, being investigated for men
Term
Levonorgestrel (Mirena, Plan B)
Definition
Intrauterine Contraceptive, also used as morning after pill
Term
Medroxyprogesterone (Provera)
Definition
PO for amenorrhea, and palliation of certain cancers (injection)
Term
Norethindrone Acetate (Aygestin)
Definition
used in combo for contraceptives, or alone for amenorrhea
Term
Norgestrel (Ovrette)
Definition
contraceptive (most effective in combo)
Term
Progesterone (Generic)
Definition
contraceptive and in fertility programs; treats amen
Term
Progestins
Definition
Inhibits FSH & LH. Transforms the proliferative endometrium into a secretory endometrium. Prevents follicle maturation and ovulation. Inhibits uterine contraction.
Term
Estrogen Contraindications
Definition
vaginal bleeding, breast cancer or estrogen-dependent breast cancer, clot disorders, CVA, heavy smokers, hepatic dysfunction, metabolic bone disease, renal insufficiency.
Term
Progestins Contraindications
Definition
PID, STDs, Endometriosis, pelvic surgery b/c the affects of vasculature of the uterus.
Caution in PTs w/ epilepsy, migranes, asthma, or cardic/renal dysfunction
Term
Drospirenone Contraindications
Definition
PT at risk for hyperkalemia due to renal disorders, liver disease, and adrenal dysfunctions.
Term
Estrogens Side Effects
Definition
breakthrough bleeding, menstrual irregularities, dysmenorrhea, amenorrhea, changes in libido, fluid retention, electrolyte disturbances, headache, dizziness, mental changes, weight changes, edema, nausea, vomiting, abdominal cramps, bloating, colitis, acute pancreatitis, cholestatic jaundice, hepatic adenoma
Term
Progestins Dermal Patch Side Effects
Definition
fluid retention, electrolyte disturbances, headache, dizziness, mental changes, weight changes, edema + skin irritaion
Term
Progestins Vaginal Gel Side Effects
Definition
fluid retention, electrolyte disturbances, headache, dizziness, mental changes, weight changes, edema + nervousness, breast enlargement, perineal pain
Term
Progestins IUD Side Effects
Definition
fluid retention, electrolyte disturbances, headache, dizziness, mental changes, weight changes, edema + abdominal pain, endometriosis, abortion, PID, expulsion of IUD
Term
PROTOTYPE: Estradiol Adverse Effects
Definition
Corneal changes, photosensitivity, peripheral edema, chloasma, hepatic adenoma, nausea, vomiting, abdominal cramps, bloating, breakthrough bleeding, changes in menstrual flow, dysmenorrhea, premenstrual-like syndrome
Term
PROTOTYPE: Norethindrone Acetate Adverse Effects
Definition
Venous thromboembolism, loss of vision, diplopia, migraine, rash, acne, chloasma, alopecia, spotting, amenorrhea, fluid retention, edema, increase in weight
Term
PROTOTYE: Raloxifene (Evista)
Definition
prevention and treatment of osteoporosis; increases bone mineral density w/out stimulating endometrium, reduces risk of breast cancer in post menopausal women with osteoporosis
Term
Toremifene (Farestone)
Definition
used as an antineoplastic agent for treatment of advanced breast cancer in post menopausal women with estrogen receptor-positive and estrogen receptor -unknown tumors
Term
Estrogen Receptor Modulators (Raloxifene & Toremifene)
Definition
stimulate some estrogen receptor sites and block others while limiting the adverse effects
Term
PROTOTYE SE: Raloxifene (Evista)
Definition
GI upset, nausea, vomiting, fluid imbalance, headache, dizziness, visual changes, mental changes, hot flashes, skin rash, edema, vaginal bleeding, venous thromboembolism, depression
Term
Fertility Drugs
Definition
Directly stimulate follicles and ovulation or stimulate the hypothalamus to increase FSH & LH levels leading to ovarian follicular development and maturation of ova.
Term
Menotropin
Definition
stimulates spermatogenesis in men with low sperm counts
Term
PROTOTYPE SE: Clomiphene (Clomid)
Definition
Risk of multiple births and birth defects, ovarian overstimulation (abdominal pain, distention, ascites, plural effusion), headache, fluid retantion, nausea, bloating, uterine bleeding, ovarian enlargement, gynecomastia, febrile reactions, vasomotor flushing, visual changes, vomiting, breast tenderness
Term
Uterine Motility Drugs
Definition
Stimulate uterine contractions to stimulate labor (oxytocics) or induce abortion (abortifacients)
Term
Terbutaline
Definition
beta2-adrenergic agonist, used as a uterine motility agent to relax the gravid uterus to prolong pregnancy. To prevent premature labor.
Term
Oxytocics
Definition
acts like hypothalamic hormone oxytocin, stored in the posterior pituitary. Stimulate uterine contractions.
Term
Oxytocics Indication
Definition
Stimulate contraction of the uterus. Also stimulates the lacteal glands in the breast to contract, promoting milk ejection in lactation women. Prevention and treatment of uterine atony after delivery, important to prevent post partum hemorrhage.
Term
PROTOTYPE SE: Oxytocin
Definition
Uterine rupture, uterine spasm, uterine hypertonicity, postpartum hemorrhage, decreased fetal HR, nausea, headache, dizziness, ertotism, water intoxication with coma, arrythmias, HTN
Term
Abortifacients
Definition
Used to evacuate uterine contents via intense uterine contractions
Term
Abortifacients Indications
Definition
Stimulates uterine activity, dislodge any implanted trophoblast, abd preventing implantation of any fertilized egg. Terminating pregnancy at 12-20 weeks. Controls post partum hemorrhage and uterine atony that does not respond to other therapy.
Term
Fertility Drugs Contraindications
Definition
Primary ovarian failure, thyroid or adrenal dysfunction, ovarian cysts, pregnancy, idiopathic uterine bleeding, breast feeding, thromboembolic disease, respiratory disease
Term
Abortifacients Contraindications
Definition
after 20 weeks from the last menstrual period, active PID, (acute cardiovascular, hepatic, renal, or pulmonary disease), during lactation, asthma, HTN, adrenal disease, acute vaginitis, scarred uterus
Term
Oxytocin Contraindications
Definition
chephalopelvic dysproportion, unfavorable fetal position, complete uterine atony, early pregnancy, coronary disease, HTN, previous cesarena births, hepatic or renal impairment
Term
Abortifacients SE:
Definition
abdominal cramping, heavy uterine bleeding, perforated uterus, uterine rupture, headache, nausea, vomiting, diarrhea, diaphoresis, backache, rash, paresthesia, hypotension, uterine or vaginal pain, chills, fever
Term
Abortifacient Prototype
Definition
Dinoprostone
Term
Fertility Drug Prototype
Definition
Clomiphene
Term
Estrogen Receptor Modulator Prototype
Definition
Raloxifene
Term
Progestins Prototype
Definition
Norethindrone Acetate
Term
Estrogen Prototype
Definition
Estradiol
Term
Androgens
Definition
male sex hormone, testosterone is a primary natural androgen. Used for replacement therapy in hypogonadism (under developed testes) and to treat certain types of breast cancer. Increases retention of Nitrogen, Na, K, Phosphorus and decrease Ca.
Term
Androgens Idications
Definition
Responsible for puberty. Protein anabolism. Increase production of RBC. Block FSH & LH in women, prevention of post partum breast engorgement.
Term
Androgens Contraindication
Definition
During pregnancy and lactation, prostate or breast in men, liver dysfunction, cardiovascular disease
Term
Androgens SE
Definition
acne, edema, hirsutism, deepening of the voice, oily skin and hair, weight gain, decrease in breast size, testicular atrophy, flushing, sweating, vaginitis, nervousness, emotional lability, headache, dizziness, sleep disorder, fatigue, rash, altered serum electrolytes, hepatocellular cancer
Term
Androgens Drug-Laboratory Test Interference
Definition
PT taking androgens, there may be decreased thyroid fxn and increased creatinine and creatinine clearance... results not associated with disease states.
Term
Androgen Prototype
Definition
Testosterone
Term
Anabolic Steroids Idications
Definition
promote body tissue-building processes, reverse catabolic processes, increase Hgb and RBC mass. Treat anemias, certain cancers, angioedeme, promote weight gain and tissue repair, and protein anabolism
Term
Anabolic Steroids Prototype
Definition
Oxandrolone
Term
Anabolic Steroids Contraindications
Definition
presence of liver dysfunction, coronary disease, prostate or breast cancer in males
Term
Anabolic Steroids SE
Definition
In prepubertal males have phallic enlargement, hirstutism, increased skin pigmentation (virilization).
Postpubertal males: inhibition of testicular fxn, gynecomastia, testicular atrophy, priapism, baldness, change in libido.
Women: hirstutism, hoarseness, deepening of the voice, clitoral enlargement, baldness, menstrual irregularities.
General: Serum electrolyte changes, liver dysfunction, insomnia, weight gain
Term
Drugs for treating penile erectile dysfunction PROTOTYPE
Definition
Sildenafil (Viagra, Revatio)
Term
Sildenafil Indications
Definition
increases nitrous oxide lvls in the corpus cavernosum activating the enzyme zGMP which causes smooth muscles relaxation allowing the flow of blood into the corpus cavernosum.Also approved for treatment of pulmonary arterial HTN.
Term
Sildenafil Contraindications
Definition
anatomical obstruction or condition that might predispose to priapism, with penile implants, bleeding disorders, CAD, active peptic ulcer, retinitis pigmentosa, optic neuropathy, hypotension, severe HTN, congenital prolonged QT interval, severe hepatic and renal disorders.
Term
Sildenafil SE
Definition
priapism, fibrosis, rash, headache, flushing , dyspepsia, UTI, diarrhea, dizziness, possible optic neuropathy, possible VIII cranial nerve toxicity, loss of hearing
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