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Exam 5 Automation & POCT
Unit 5 Lecture 6 Taking Over Technology
40
Chemistry
Undergraduate 3
04/15/2015

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Term
Hospital POCT requires
Definition
Instrument validation, calibration, QC, operator training and proficiency testing
Term
Common POC Applications
Definition
Glucose, Electrolytes, Blood gases, drugs
Chol / TG, Cardiac markers (troponin), creatinine
Activated clotting time, PT, PTT
Term
Analytical techniques for POCT
Definition
Spectrometry / Reflectance photometry
/ Paper chromatography/ ISE
Biosensors using micro silicon chips
Term
Modular Automation
Definition
One section of a lab is automated at a time
Term
Total Laboratory Automation (TLA)
Definition
Sample processing (pre-analytical phase), analysis (analytical phase), and report generation and sample storage (post-analytical phase)
Term
Hospital information system (HIS)
Definition
hospital-wide system that generates patient reports and orders
Term
Laboratory information system (LIS)
Definition
Generates test requests and results.
Generates worksheets
Term
True or False:
Many analyzers are directly linked to the LIS
Definition
True
Term
Bidirectional interface
Definition
2-way communication between the LIS & any on-line instrument
Term
Data Handling
Definition
Computerized monitoring of QC, clot detection, temperature, reagent levels
Term
Dry Slide
Definition
All chemicals are layered onto
a thin slide on a plastic support
Term
How is the shelf life of Dry Slide?
Definition
Long shelf life; 6 month calibration possible
Term
True or False:
Reagent systems Dry Slide - The only liquid used in the system is patient sample; no plumbing or drains
Definition
True
Term
True or False:
Dry Reagent Systems require reconstitution
Definition
True
Term
True or False:
Dry Reagent Systems - water quality is very important
Definition
True
Term
How often do Liquid or Wet Reagent Systems require instrument calibration?
Definition
Daily to Monthly
Term
What is the disadvantage of Liquid or Wet Reagent Systems?
Definition
Faster expiration dates
Term
Throughput
Definition
maximum number of tests that an instrument can perform in a given period of time
Term
Simultaneous Multiple Analyzer
Definition
Continuous flow, multiple channels allowed 6 or 12 tests to be run on a single sample; 360 or 720 tests per hou
Term
Automatic Clinical Analyzer (ACA)
Definition
Discrete random access analyzer
Term
True or False:
The ACA is Able to process different tests simultaneously as they pass through the system (simultaneous multiple analysis)
Definition
True
Term
Dry Slide Technology,Kodak
Definition
Use micro-volumes of sample and reagents
-Eliminated liquid waste and liquid reagent prep and storage
Term
Continuous Flow
Definition
Samples, standards, controls, diluents and reagents travel through a system of continuous tubing
Term
How were samples separated with continuous flow
Definition
Air bubbles
Term
What were the past problems with continuous flow
Definition
Carryover and wasted reagent
Term
What has helped to reduce carryover?
Definition
Teflon tubing & Teflon oil
Term
Test Menu or Repertoire
Definition
The list of tests that can be run on an instrument
Term
Dedicated Instrument
Definition
Designed to perform 1 or 2 tests ONLY
Term
Glucometer is an example of what kind of instrument?
Definition
Dedicated Instrument
Term
True or False:
Separate probes (tips) are used for each sample in Specimen measurement and delivery
Definition
True
Term
How is sample evaporation reduced in automated analysis?
Definition
lid covers, sample caps that can be pierced, or cuvette sealing devices
Term
What is the most labor-intensive phase of testing?
Definition
Specimen Processing and Identification
Term
What is the most costly phase of testing?
Definition
Specimen Processing and Identification
Term
Discrete Analyzers
Definition
Each sample has its own separate container, tube or cup
Term
True or False:
Discrete Analyzers can run multiple tests on one sample
Definition
True
Term
True or False:
Discrete Analyzers can run one test on multiple samples
Definition
True
Term
Discrete Analyzers - Random Access Capability allows for what?
Definition
STAT out-of-sequence analysis regardless of initial sample loading order
Term
Centrifugal Analyzers
Definition
Centrifugal force mixes and transfers samples from chamber to chamber
Term
What are Centrifugal Analyzers used primarily for?
Definition
High Volume Batch Analysis
Term
True or False:
Centrifugal Analyzers - All test cuvettes are read simultaneously, so cuvettes must be matched
Definition
True
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