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Exam 3
Lecture 9
38
Anatomy
5th Grade
05/02/2013

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Term
what is the class II drug?
Definition
esmolol
Term
what are the effects of esmolol- 3
Definition
decrease heart rate
decrease action potenial in the SA
decrase conduction in the AV node
Term
which drug has a recovery time of 15 min once terminated
Definition
esmolol
Term
what type of elmination does esmolol have
Definition
renal
Term
what patients should you caution the use of esmolol in? -3
Definition
diabetes
HF
bronchospasm disease
Term
contrainidcaiton for the use of esmolol-3
Definition
AV block 2n3 3rd degree
severe HF
cardio shock
Term
what are the class three drugs
Definition
amiodarone
dronedarone
dofetilide
Sotalol
Ibutilidie
Term
what is main target for amiodarone?
what else does it block?-3
Definition
K channel
Na, Ca, and adrenergic
Term
what drug prolongs PR, QT, and QRS
Definition
amiodarone
Term
what are the 4 effects of amiodarone
Definition
prolong action potential
prolong refractory
inhibit cell coupling
inhibit abnormal automaticity
Term
which drug has a structure like thyroid hormone
Definition
amiodarone
Term
amiodarone is highly lipophobic/philic?
what does this do-
Definition
philic
eliminated very slowly!
Term
how is amiodarone elminated
Definition
hepatic
Term
what are some severe ADEs of amiodarone-3
Definition
pulmonary fibrosis
deposits on cornea
QT prolongation
Term
caution the use of amiodarone in what patients-3
Definition
prexisitng QT prolong
respiratory distress
optic neuropathy
Term
contrinidcations for amiodarone -3
Definition
SA dysfunction
2nd-3rd degree AV block
syncope
Term
how does dronedarone differ from amiodarone-2
Definition
less lipophillic
less thyroid like
Term
main ADEs of dronedarone-3
Definition
QT prolongation
asthenic (loss of energy)
skin(dermiitis)
Term
caution use of dronedarone in-4
Definition
HF
hepatic impariment
electrolyte imabalnce
igh digoxin
Term
which drug increase mortality in ppl with permanent atrial fibrilation
Definition
dronedarone
Term
which drug is the pure blocker of K channels?
Definition
dofetilide
Term
what are the effects of dofetilide-2
Definition
prolonged refractory and action potentialo in atria and ventricles
Term
which class III drug prolongs QT, but not PR or QRS
Definition
dofetilide
Term
which class III drugs are proarrythmic?-3
-what are they espeically prone to?
Definition
dofetilide & sotolol & ibutilide
torsaeds de pointes
Term
what is the normal range for potassium
Definition
3.5-5
Term
what drugs do you caution the use with dofetilide-2
what drugs are contraindicated- 5
Definition
k depleting diuretics
drugs that prolong QT;
verapamil, cimetadine, trimethorpim, ketoconazole, HCTZ
Term
which drugs must be started under close ECG monitoring-3
Definition
dofetilide
sotalol
ibutilide
Term
which Class III agent also blocks B1 and B2 receptors?t
at what dose does it start doing it at?
what dose does it start doing the K at
Definition
sotolol
25 mg
160 mg
Term
caution use of sotalol in what patients-4
Definition
renal impaired
HF
hypokalemia
hypomagnesium
Term
sotalol is contraindicated if potassium concentration is below what?
Definition
3.5
Term
which class III drug inhibits potassium and also maybe Na
Definition
ibutilide
Term
what is the only contraindication for ibutilide
Definition
hypersenssitivty
Term
what are the class 4 agents-2
Definition
diltiazem
verapamil
Term
what factors do warfarin inhibit
Definition
2 (prothrombin),7a, 9, 10
Term
what does rivaroxaban inhibit
Definition
directly inhibits 10a
Term
what does dabigatran inhibit
Definition
direct inhibitor of thrombin (IIa)
Term
rivaroxiban vs dabigatran:
elimination:
dose adjustments on Cr CL:
drug interactions:
Definition
R= liver, D- renal
if less than 50 for R, <30 for D
R= 3A4; D= PgP
Term
what is the antidote for bleeding for rivaroxiban and dabigatran?
Definition
none needed
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