Shared Flashcard Set

Details

Exam 3
Drug Receptor Binding and Affinity
9
Pharmacology
Professional
11/11/2010

Additional Pharmacology Flashcards

 


 

Cards

Term

T/F

Under Law of Mass Action we assume that binding is totally reversible

Definition

TRUE

 

Term
What is Kd?
Definition
The [drug] at which binding is half maximal
Term

Which has a greater affinity?

Kd=25pM

Kd=3pM

Definition

Kd=3pM

it takes less drug to bind to the receptors

Term
What gives receptors their shape?
Definition
Membrane
Term

T/F

a drug will always bind to its receptor

Definition

FALSE

it may bind to other membrane proteins

Term

Labeled and unlabeled drug determine_____

total binding

nonspecific binding

receptor binding

Definition
NON specific binding
Term

T/F

at a lower Kd, it takes a small [drug] to be 1/2 saturated

Definition
TRUE
Term
When looking at a scatchard plot, if the graph has 2 paralell lines what does this mean in terms of the Kd and Bmax?
Definition

Paralell lines have the same slope which means their Kd are the same and they have the same affinity.

This tells you nothing about the Bmax (where it intersects the x-axis)

Term

[image]

What is the Bmax?

What does this number mean

Definition

Bmax~ 65

Maximum [bound ligand]

Supporting users have an ad free experience!