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Exam 2
Basic Responses of Neurons & Glia to Injruy
16
Veterinary Medicine
Professional
02/13/2017

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Cards

Term
Describe the breadth of neuro regen.
Definition
-extremely limited regen ability
Term
What does an ischemic neuron look like?
Definition
-shrunken & red
Term
What is the major thing of path we see w/ viruses affecting the CNS?
Definition
-intranuclear or intracytoplasmic inclusions in neurons
Term
What do we see on path w/ lysosomal storage d?
Definition
-vacuolation
Term
What do we see w/ spongiform encephalopathies on path?
Definition
-huge vacuoles
Term
What is Wallerian degen in axons?
Definition
-response to severing or direct axonal damage w/ which DISTAL axon undergoes necrosis
Term
Is regen better in central or peripheral nervous system?
Definition
-peripheral
Term
What is axon demyelination? Some etiologies?
Definition
-loss of oligo or Schwann cells
-distemper, CAE, globoid cell leukodystrophy, Afghan myelopathy
Term
Via axonal regen (Wallerian degen) regen is by axonal ______.
Definition
-budding
Term
Are astrocytes or neurons more susceptible to ischemic damage?
Definition
-neurons
Term
How do astroycytes respond w/ non=lethal rxns?
Definition
-function to fill in or wall off areas of necrosis
-small area: astrocytes proliferate to form a glial scar (focal gliosis)
-large area: wall off and leave cystic space
Term
Are astrocytes or oligos more susceptible to ischemia?
Definition
-oligos slightly more
Term
Where do CNS macrophages come from?
Definition
-microglia
-peripheral blood monocytes
Term
Which cells are least susceptible to ischemic injury?
Definition
-microglia
Term
What do microglia cells do in response to ischemic injury?
Definition
-ingest lipids beocming Gitter Cells
-eat necrotic neurons (called neuronophagia)
-eat red cells and become hemosiderin-laden (siderophages)
Term
What are gitter cells? From what are they derived? Major stimuli?
Definition
-lipid-laden (foamy) macrophages in brain
-infiltrating blood monocytes or proiferating microglia-
-degen myelin and necrosis in brain
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