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Exam 2
Lecture 3- Part 2
47
Anatomy
4th Grade
02/07/2013

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Term
when do you use gonadotpropins?
Definition
when clomephine fails
Term
wht are 3 negative points about gonadotropins
Definition
expensive
parenteral daily
extensive monitoring
Term
what are the gonadoptropins -4
Definition
LH
FSH
hCG
Term
whatare the glycoproteins that make up pituitray hromones-4
Definition
TSH
LH
FSH
hCG
Term
structure of gonadotropins
Definition
glycosyltaed heterodimer- alpha and beta subunit
Term
gonadotropin in males does what
Definition
stimulte spermatogensis
Term
gonadotropin therapy in females does what
FSH-
LH
Definition
maturation and devlopment of follicle
ovulation and corpeus luteum
Term
to use gonadoptropins in females the ovaries must be able to do what?
Definition
respond to Lh an dFSH
Term
route of admin for gonadoptropins (think proteins)
Definition
IM
Term
storage for gonadotropin
Definition
powder- room or fridge
Term
females use gonadotropin- 2
Definition
hypothalmic anovulation
ovulation for failed clomipehene
Term
what med do you use to stimulate the follicles for ART
Definition
gonadoptropins
Term
use of gonadoptropins in males
Definition
speratogensis with 1 or 2nd hyopgonadism
Term
hCG would well in women infetile due to lack of?
how is it admin?
Definition
midcycle gonadoptrin surge
IM
Term
hCG activty is idneticle to?
which has longer half life?
Definition
LH
hCG
Term
what can hCG do in males
Definition
speratogensis with pituitary hypofunctino
Term
ADEs of hCG -5
Definition
headache, fatigue, edema, gynectsomia, pain of injction
Term
what are the hCG meds-
urine-2
r-hCH-1
Definition
pregnyl
novarel
ovidarel
Term
what is the MOA of hCG
Definition
supplements LH for LH surge
Term
female injects hCG- what is the rule for intercoiurse?
Definition
should have after injection and next 2 days
Term
hCG for males 2nd to hypogonadism
Definition
100-200 2-3 x/week until normal testosteon
Term
storage for the urine derived hCG?
for the r-hCG
Definition
RT until mixed- then fridge
fridge until dispnesed to patient
Term
when do you use hCG in women-2
Definition
for ovulation WITH other agents
correct lack of mid cycle gonadotropin surge
Term
what is the decapeptide rleased by the hypothalmus?
where does it go?
Definition
GnRH
portal circulatory to pituitary
Term
which is better for pituitary response-
pulistile or continuous GnRH
Definition
pulsitile
Term
what is the GnRH med?
how is it admin?
Definition
Gonadorelin/Lutrepulse
portable pump- IV or SQ
Term
ADE of Gonadorelin
Definition
ovary hyperstimulation
multiple gestations
Term
what does overstimulation ovary syndrome lead to?
what does VEGF have to do with it?
Definition
cysyts
hyper permeable blood vessels- fluid from vasdcular comes to pleurual/abdominal
Term
GnRH agonists have longer/shorter half life than normal GnRH
Definition
longer
Term
what two ways cna you give the GnRH agonists?
Definition
trnasient
multiple formulation (short or long duration)
Term
what does trarnasient GnRH do? -2
Definition
down regulate GnRH recpotr
inhibit gonadotropin secretino
Term
multiple formulaitons of GnRH agonits are used to do what?
Definition
decreased number of oocytes release prematurely
improve oocyte leading
Term
pulsitiel delivery of GnRH agonsits stimulates what?
Definition
gonadotropin release from pituitary
Term
continuous delivery of GnRH does what for gonadoptropin relasE?
Definition
increae for a while- but then shuts it down
Term
GnRH side effects-3
Definition
excess ovary stimulation
excess estrogen- breast tedner, vaginal bleeding
estrogen deficiency- hotflashes, headache
Term
what are the suffix fr GnRH agonists
Definition
leuprolide or relin
Term
what is the long term GnRH therapy for?
short term?
Definition
desinsitizing
flare up
Term
for long term therapy of GnRH-
when was it started? how often dosed?
wht does it do the pituitary?
Definition
previous cycle; continuous
suppresses
Term
for short term doese of GnRH:
when do you start GnRH?
when do you start the gonadoptropins?
Definition
day 2 of cycle
day 3 of cycle
Term
what is the suffix of GnRH antagonists
Definition
relix
Term
when do you recieve GnRH antagonists?
what does it do?
Definition
those on ovarian hyperstimulants- prevents premature LH surge and premature ovulation
Term
GnRH antagonists suppress what?
what do they not have that GnRH do?
Definition
LH surge
initial flare of secretion
Term
how are GnRH antagonists administered?
bioavaialble?
Definition
SC
good
Term
storage of GnRH antagonists
Definition
fridge
Term
what are teh 2 GnRH antagonists (brand names)
Definition
Antagon
Cerotide
Term
ADEs of GnRH antagonists -4
Definition
Ovrian hyperstimulate, vaginal bleeding, N/V
Term
other agents used: -6
Definition
metformin
progestins
estrogen
guanfenisen
dopamine agonists
Low Dose Aspirin
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