Shared Flashcard Set

Details

Epithelial Cells
Cell Adhesion Molecules
6
Histology
08/30/2011
Click here to study/print these flashcards.

Create your own flash cards! Sign up here.

Additional Histology Flashcards

 

 

Cards

Term
Ca2+ Dependent Molecules
 Definition

Cadherins

 

Selectins
Term
Ca2+ Independent Molecules
 Definition

CAMs (cell adhesion molecules) of Immunoglobulin Superfamily

 

Integrins
Term
Cell Adhesion Molecule Function
 Definition

Enable Interepithelial cell contact

 

Molecules stabilized by specialized cell junctions
Term

Cadherins:

 

Main Purpose

 

Where are they found

 Definition

Cadherins are the main adhesion protein holding epithelial cells together in a sheet arrangement

 

They are present between cytoplasmic plaques of zonula and macula adherens
Term
Cadherin Structure
 Definition
  • 4 domains in extracellular portion cadherin
    • these domains bind Ca2+
  • Binding Face: His-Val-Ala
    • The binding face facilitates the formation of cis-homophilic dijmers
    • It then stabilizes a trans-homophilic dimer with dimers of opposite cell membrane
Term
 Definition