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Endocrinology (physio)
Intro Lecture
10
Physiology
Graduate
03/11/2011

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Cards

Term
Zeitgebers
Definition
external cues that influence rhythmicity of hormone secretion
Term
Suprachiasmatic nucleus
Definition
-pacemaker for circadian rhythms
-cluster of nerve cell bodies above optic chiasm in hypothalmus
Term
Hormone Receptor Complex
Definition
hormone response element that binds to a region of DNA in the nucleus.
Term
Permissiveness
Definition
1 hormone must be present in adequate amounts for the full effect of another hormone. (Testosterone increases # of EPI receptors so that EPI can have full effect)
Term
Synergism
Definition
combined effect is greater than the sum of separate efforts (T and FSH together for optimal sperm production)
Term
Antagonism
Definition
when 1 hormone causes the down-regulation of another hormone's receptors (P causes loss of E receptors on uterine sm muscle to prevent contractions until labor)
Term
Causes of Hormone Deficiency
Definition
-autoimmune dz
-surg
-mutations in hormone, receptors, tr. factors, enzyme channels
Term
Causes of hormone excess
Definition
-ectopic tumor
-autoimmune dz
-excess hormone admin during tx
Term
Causes of hormone resistance
Definition
-defect in receptor or signal transduction pathway
-defective hormone actions despite increased levels
Term
Antagonists
Definition
molecules that bind to the receptor and BLOCK binding of agonist; failure to trigger intracellular signaling events
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