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ENDOCRINE PHARM
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63
Accounting
Pre-School
04/19/2013

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Cards

Term
Rapid acting insulin
Definition
Lispro, Aspart
Term
Short acting insulin
Definition
Regular
Term
Intermediate acting insulin
Definition
NPH
Term
Long acting insulin
Definition
Glargine, Detemir
Term
Close K+ channel in beta cell membranes, so cell depolarizes triggering of insulin release via increase calcium influx
Definition
sulfonylureas
Term
Sulfonylureas 1st gen
Definition
Tolbutamide
Chlorpropamide
Term
Sulfonylureas 2nd gen
Definition
Glyburide
glimepiride
Glipizide
Term
Insulin type drugs which cause hypoglycemia
Definition
Insulin, Sulfonylureases 2nd gen, Pramlintide( Mimetic)
Term
Hyperglycemic drug which causes disulfiram like effects
Definition
Sulfonylurease 1st gen
Term
Sulfonylurease that you have to decrease dose in:
Hepatic dysfxn
Renal dysfxn
Definition
Hepatic problems= decrease dose of glipizide
Renal problesm= decrease dose glyburide
Term
Increase gluconeogenesis and increase glycolysis in the liver while increasing peripheral glucose uptake
Definition
Biguanides (metformin)
Term
Side effect of metformin
Definition
Lactic acidosis and wt. gain
Term
Increase insulin sensitivity in peripheral tissues. Fat and muscle
Definition
Glitazones (-zones)
Term
Glitazones bind what?
Definition
PPAR-gamma nuclear transcription regulator to change gene expression. Increase insulin receptor #'s
Term
Inhibit intestinal brush boarder alpha-glucosidase by delaying sugar hydrolysis and glucose absorption
Definition
Acarbose
Miglitel
Term
Hyperglycemic med which only decreases glucagon release
Definition
Mimetics (pramlintide)
Term
These hyperglycemic meds increase insulin release and decrease glucagon release
Definition
GLP1-analogs (Exanatide)
Term
Block peroxidase and inhibiting organification of iodide and coupling of thyroid hormone synthesis
Definition
Propylthiouracil
methimazole
Term
Action which propylthiouracil has but methimazole lacks
Definition
Blocking of 5 deiodinase
Term
Side effects of Propylthiouracil and Methimazole
Definition
Skin rashes
agranulocytosis
Term
Which can be used in pregnancy: Propylthiouracil or methimazole
Definition
Propylthiouracil
Term
2 drugs used in hypothyrodism or myxedema
Definition
Levothyroxine
Triiodothyronine
Term
GH analog
Definition
Somatotropin
Term
Somatotropin is used for (4)
Definition
GH deficiency
Turner syndrome
Pituitary dwarfs
Osteoporosis
Term
Somatostatin analog
Definition
Ocreotide
Term
Ocreotide (4)
Definition
Acromegaly
Carcinoid
Gastrinoma
Glucagonoma
Term
Analog of ADH
Definition
Desmopressin (V2)
Term
Desmopressin used for what (3)
Definition
Pituitary (central) diabetes insipidus
Hemophilia A
Von Willibrand disease
Term
ADH antagonist used in SIADH
Definition
Demeclocycline
Term
Inhibits leukotriens and prostaglandins by inhibiting phopholipase A2 + expression of COX2
Definition
Glucocorticoids
Term
Side effects of Glucocorticoids
Definition
Iatrogenic cushingoid syndrome
hyperglycemia
Osteoporosis
Adrenal Insufficiency
Term
GnRH analog and the two different uses
Definition
Leuprolide

Pulsatory: Agonist
Continuous: antagonist
Term
Leuprolide use when pulsatory
Definition
Infertility
Term
Leuprolide use when constant
Definition
Prostate cancer
Term
Agonist at the androgen receptrors
Definition
Methyltestosterone
Term
Methyltestosterone uses
Definition
Hypogonadism
Promotes secondary sex characteristics
Kleinfelters
Term
5 alpha reductase inhibitor and use
Definition
Finasteride used for BPH and male pattern baldness
Term
A nonsteroidal competitive inhibitor of androgens at the testosterone receptor
Definition
Flutamide
Term
Inhibits steroid synthesis
Definition
Ketocanazole
Term
Inhibits steroid binding
Definition
Spironolactone (aldosterone)
Term
Side effect of DES
Definition
clear cell carcinoma
Term
Side effects of estrogen use
Definition
endometrial carcinoma and bleeding
Term
Estrogen use Contraindicated in
Definition
Breast cancer, DVTs
Term
Estrogen use (6)
Definition
Hypogonadism
Ovarian failure
Menstrual abnormalities
Contraception
HRT for post menopausal women
Prostate cancer in men
Term
partial agonist @ estrogen receptors in hypothalamus
Definition
Clomiphene
Term
Clomiphene use
Definition
Infertility
PCOS
Term
Clomiphene SE
Definition
Multiple pregnancies (quadruplets)
Term
Antagonist on breast tissue, agonist at bone tissue, and partial agonist at the endometrium
Definition
Tamoxifen
Term
Tamoxifen use
Definition
ER+ breast cancer
Term
SERM used in osteoporosis
Definition
Raloxifene
Term
Tamoxifen can cause what cancer
Definition
Endometrial
Term
Aromatase (-) used in post menopausal women w/breast cancer
Definition
Anastrozale/exemestane
Term
Side effects of progestin use
Definition
Increase LDL/decrease HDL
androgenic (hirsitism/acne)
antiestrogenic
Glucoseintolerance
Term
Competitive inhibitor of progestins at progesterone receptors
Definition
Mifepristone
Term
Mifepristone used with what for what
Definition
Misoprostel (PGE1) and to terminate pregnancy
Term
Contraindications of OC's
Definition
Smoking
>35
Thromboembolism
Stroke
Estrogen-dependent tumor
Term
Estrogen and Progestins MOA in OC's
Definition
Estrogen=inhibits LH/FSH and estrogen level is always constant and never surges so decrease ovulation

Progesterone= Thickening of cervical mucus limiting access of sperm and inhibits endometrial proliferation.
Term
B2 agonists that relax the uterus, reduce premature uterine contractions
Definition
Ritodrine
Terbutaline
Term
alpha1-antagonist used to treat BPH by inhibiting smooth muscle contraction. Also what alpha receptor is it selective for
Definition
Tamsutosin alpha 1a or 1d receptors
Term
Inhibit cGMP phosphodiesterase, causing smooth muscle relaxation in the corpus cavernosum, Increase blood flow, increase erection
Definition
Sildenafil, Vardenafil
Term
Side effects of Sildenafil
Definition
Flushing
Blue Green vision
Life threateing Hypotension when given with NITRATES
Term
Synthetic androgen that acts as a partial agonist @ androgen recptors
Definition
Danazol
Term
Danazol uses (2)
Definition
Endometriosis
Hereditary angioedema
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