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Endocrine-Pharm
Thyroid and Antithyroid Agents
7
Pharmacology
Graduate
11/04/2010

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Cards

Term
Why are thyroid levels so critical in developing child?
Definition
Hypothyroid during development can cause severe mental retardation
Term
What are some drug interactions seen with thyroid replacement
Definition

Thyroid hormone: Increases catabolism of digitalis and Vit K-Dep Factors(increasing anti-coagulant action)

Amiodarone-Hypo or sometime Hyperthyroid

Phenytoin, Rifampin, Carbamazepine increase thyroid catabolism

Term
What are the treatment options for Hyperthyroid and when would each be used?
Definition

131 iodination/Thyroidectomy: adult

Thioureas: Kids or Pregnant

Term
What are the complications of the different treatments of Hyperthyroid
Definition

131 or Thyroidectomy: Thyroxine requiring hypothyroidism

Thioureas: Skin Rash, Goiter

Term
What is the treatment of choice for a pregnant women who is hyperthyroid
Definition

PTU during first trimester because it does not cross the plecental/ breast milk barrier as readily as methimazole

Methimazole for 2nd and 3rd

Term
How would you treat a patient after exposure to radioactive iodide?
Definition
High dose Iodide to dilute the concentration in the thyroid
Term
What drugs are typically used in the treatment of Thyrotoxicosis?
Definition
Beta-blockers: Propranolol(good CNS penetration), Esmolol(Acute Thyroid Storm)
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