Shared Flashcard Set

Details

Endocrine-Pharm
Sugabetes Drugs
10
Pharmacology
Graduate
11/01/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
What diabetic drugs carry the worst risk of hypoglycemia?
Definition
Sulfonlureas
Term
What are the names of the common Sulfonylureas
Definition

Tolbutamide

Tolazamide

Chlorpropamide

Glyburide

Glipizide

Glimepiride

Term

What is the mechanism of Sulfonylureas?

What is the adverse effect?

Definition

Reduce K channel conductance-> insulin release

Adverse: Hypoglycemia

Term

What is the mechanism of action of Metformin

What is the adverse effect?

Definition

Decreases Liver gluconeogenesis

Increases glucose uptake in the periphery

Requires insulin

Adverse

Anorexia

Metallic Taste

Term

What is the Mechanism of Action of Acarbose

What is the major adverse effect?

Definition

Blocks Alpha-Glucosidase slowing Glucose absorption in the GI

Adverse: Fe Malabsorption

Term

Pioglitazone/ Rosiglitazone mechanism of action

What are the adverse effects?

Definition

Bind PPAR-Gamma receptor to increase the expression of insulin responsive genes

Adverse

Heart failure

Bone Fracture

Term
What is the mechanism of Repaglinide, Natetaglinide
Definition

Closes potassium channels like Sulfonylureas

Shorter acting than Sulfonylureas-> less hypoglycemia

Term
What is the mechanism of action of Exenatide
Definition

Stimulates insulin secretion when blood sugar is high

Blocks glucagon release

Delays gastric emptying

Term
What is the mechanism of action of Pramlintide
Definition

Amylin homolog-> decreased Glucagon

 

Term
What is the mechanism of action of Sitagliptan and what are the side effects
Definition

Inhibit Dipeptidyl-peptidase 4->

Decreases incretin breakdown(GLP)->

more insulin, less glucagon

Supporting users have an ad free experience!