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Endocrine-Path
Endocrine Screening in the Clinical Lab
8
Pathology
Graduate
11/04/2010

Additional Pathology Flashcards

 


 

Cards

Term
What are some challenges to the screening of endocrine disorders?
Definition

Sensitivity to pick up the small levels of hormones

Specificity to prevent cross reactivity

Multiple Hormone forms from Post-trans Mod

Bound vs Free Forms

Homone Fluctuations

Multiple levels causes same clinical disease

Term
What is the most commonly used endocrine testing
Definition
Thyroid Testing
Term
How is thyroid screening assessed?
Definition

TSH levels, If abnormal do FT4

T3, If TSH low and FT4 normal

Anti-Thyroid substances, If TSH elevated

 

 

Term
How is Adrenocortical Hyperfunctioning assessed?
Definition

24 hr free Cortisol

Primary: if low ACTH and High Cortisol

Secondary: if high ACTH and High Cortisol

Ectopic ACTH production does not respond to dexamethasone

Term
What are some common casues of Hypercalcemia
Definition

Vit D Intoxication

Primary and Secondary Hyperparathyroid

Sarcoid

Myloma

Excessive Intake

Hyperthyroid

Immobilization

Term
What are some causes of Hypocalcemia
Definition

Hypoparathyroidism

Vit D Deficiency

Malabsorption

Pancreatitis

Transfusion

Term
How do you screen for a Pheochromocytoma?
Definition
Urinalysis for Norepinephrine, Epinephrine, VMA levels
Term
What are some common factors that alter catecholamine production?
Definition

Caffeine, Nuts, Bananas

MAO-Inhibitors

Alpha-Methyldopa

Dopamine

Stress

Isoproterenol

Quinidine

 

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