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Details

Endocrine-ICM
Hypothyroidism
17
Medical
Graduate
11/03/2010

Additional Medical Flashcards

 


 

Cards

Term
What are some key steps in the formation of thyroxine
Definition

Sodium-Iodine Symport

Thyroperoxidase

Deiodiodinase

Term
What is the majority of thyroid hormone released from the thyroid gland composed of, and how does it circulate in the blood
Definition
T4, circulates mostly bound to TBG
Term
What is the activated form of Thyroid hormone and how does it become activated
Definition
T3, activated by deiodination in periphery
Term
How does thyroid hormone induce peripheral tissues
Definition
Amino acid hormone that acts at a Nuclear receptor like steroids
Term
What are some signs that would make you suspicious of hypothyroidism?
Definition

Cold intolerance

 Skin changes

Alopecia

Psych changes

Weakness

Term
What are some things to be cognisant of in using TSH screening test
Definition

Pregnancy

Pituitary Disease

Term
What would the TSH and T4 level be in primary verses secondary hypothyroidism
Definition

Primary: High TSH, Low T4

Secondary: Low TSH, Low T4

Term
What is the clinical manifestation of untreated congenital hypothyroidism and why is it screened for?
Definition

Cretinism

Mental retardation occurs if untreated

Term
What are some common medications that can lead to hypothyroidism
Definition

Amiodarone

Lithium

Interferon Alpha

Term
Does high antibody against thyroid proteins lend a diagnosis of Hashimotos alone?
Definition
No, many euthyroid patients have these ABs
Term
How is hypothyroid screening carried out
Definition
TSH screen, if positive then TSH and T4 are screened
Term
What is the standard hypothyroid treatment and what are other less used options
Definition

Oral Levothyroxine

Less common: Combo T3/T4, Armour Thyroid

Term
What patients should you be wary of begining a higher dose of T4 initially
Definition

Very Old

CV Disorder Patients

Term
How would you monitor the treatment of a primary versus secondary hypothyroid patient differently?
Definition

Primary: TSH

Secondary: T4

Term
What are the clinical complications of Myxedema Coma?
Definition

CV collapse

Hyponatremia

Respiratory Failure

Hypothermia

Term
What is the treatment of Myxedema coma
Definition
IV levothyroxine and IV glucocorticoids
Term
What would be the reasons to get a ultrasound on a hypothyroid patient?
Definition
Goiter, or thyroid nodule on PE
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