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Eicosanoids
Drugs for Chp 41 eicosanoids
42
Medical
Post-Graduate
03/07/2011

Additional Medical Flashcards

 


 

Cards

Term
Aspirin
Definition
irreversible COX-1 and COX-2
Term
Aspirin
Definition
Reye's Syndrome
Term
Aspirin
Definition
prophylaxis of stroke and MI's
Term
Ibuprofen
Definition
Propionic Acid
Term
Ibuprofen
Definition
Rheumatoid Arthritis, Propionic Acid
Term
Naproxen
Definition

NSAID that can cause pseudoporphyria, 20X more potent than aspirin, longer half life

Propionic Acid

Term
Indomethacin
Definition
patent ductus arteriosus CLOSURE
Term
Ketorolac
Definition
Acetic Acid NSAID used for post surgery
Term
Piroxicam
Definition
Oxicams NSAID
Term
Piroxicam
Definition
long half life, potent modulator of neutrophils by inhibiting oxygen burst,
Term
Nabumetone
Definition

Ketone NSAID

COX2 > COX1

Term
Acetaminophen
Definition
COX 2 and COX 3 inhibitor
Term
Acetaminophen
Definition
anti-pyretic (fever), mild to moderate pain reliever, not an anti-inflam or anti-platelet
Term
Acetaminophen
Definition
Hepatotoxicity, nephrotoxicity
Term
Acetaminophen
Definition
overdose is the leading cause of hepatic failure
Term
N-acetylcysteine
Definition
antidote for acetaminophen overdose
Term
Celecoxib
Definition
selective inhibition of Cox -2
Term
Celecoxib
Definition
decreases efficacy of ACE inhibitors
Term
Celecoxib
Definition

Used for OA, RA, dysmenorrhea

Causes MI, GI bleeding

 

Term
MOE for Glucocorticoids
Definition
inhibit cox-2 action and prostaglandin biosynthesis by inducing lipcortins
Term
Anakinra
Definition

inhibit ILA (cytokine antagonist)

only used for RA

Term
Etanercept, Infliximab, Adalimumab
Definition

TNF-Alpha antagonist

RA and OA

Term
Prostanoid
Definition
similar structure in all prostaglandins
Term
Alprostadil, Misoprostol
Definition
PGE1 analogue with vasodilator properties
Term
Alprostadil
Definition

maintence of patent ductus arteriosus

can cause DIC

Term
Misoprostol
Definition

Used for abortifacient

PGE1 analogue

Term
Misoprostol
Definition
Cytoprotective and antisecretory effects against gastric ulcers in long-term NSAID therapy
Term
----oprost
Definition
PGE2alpha analogue
Term
Carboprost
Definition

Abortion in second trimester

( cause contractions)

- can cause dystonia and pulmonary edema

 

Term
Latanoprost
Definition
Term
Latanoprost, Bimatoprost, Travoprost
Definition

Ocular hypertension and Open angle glaucoma

can cause macular retinal edema

Term
Epoprostenol
Definition

Prostacyclin analogue that stimulates vasodilation of the pulmonary and systemic arterial vasculature

tx: Pulmonary hypertension

 

 

Term
Dazoxiben, Pirmagrel
Definition
inhibit thromboxane synthase
Term
Ridogrel
Definition
thromboxane A2 receptor antagonist
Term
5-lipoxygenase
Definition
forms leukotrienes from Arachidonic acid
Term
Zileuton
Definition
lipoxygenase inhibitor
Term
Zileuton
Definition

used for asthma because causes bronchodilation

 

Side Effect: Increased liver function tests

Term
CysLT type 1 receptor
Definition
specific receptor for leukotriene receptor antagonists
Term
Montelukast, Zafirlukast
Definition
Leukotriene receptor antagonists
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