Shared Flashcard Set

Details

EBM wk 4
Asking Questions About Therapy or Harm (LLUSOM 2014)
17
Medical
Professional
09/18/2010

Additional Medical Flashcards

 


 

Cards

Term
Intention To Treat
Definition

Answers: does the clinciain want to know how to initiate therapy?

 

Avoids ALPHA errors

 

any treatment changes after randomization are ignored and all outcomes are charged to the orignially assigned therapy

Term
Per Protocol Anaylsis
Definition
answers: does the clinician want to know what to expect after therapy has begun?

Avoids BETA errors

Subjects with treatment changes are removed or excluded
Term
Relative Risk Ratio
Definition
E/C

Will overestimate or underestimate impact of therapy when adverse events in untreated patients are very rare
Term
Relative Risk Increase
Definition
E-C/C
Term
Absolute Risk Increase
Definition
E-C
Term
Number Needed to Harm
Definition
1/E-c
Term
Relative Risk Reduction
Definition
C-E/C
Term
Absolute Risk Reduction
Definition
C-E
Term
Number Needed to Treat
Definition
1/C-E
Term
Harm: relative risk value
Definition
>1
Term
Therapy: relative risk value
Definition
<1
Term
validity
Definition
Accuracy
Term
Precision
Definition
reproductivity
Term
Confidence Interval
Definition

range withing which the true effect plasibly lies greater

 

the greater the width of CI, the less precise the observed estimate

 

(The width also increases if we raise from 90% to 95% to 99% so don't be fooled by smaller CI!)

Term
p value
Definition
evalutes the point estimate that provides the single most likely estimate of the underlying true treatment
Term
Bias
Definition
leads to either an underestimate or overestimate of the underlying beneficial or harmful effect
Term
Absolute Risk (def)
Definition
Proportion of patients in a group in whom an event is observed
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