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Dyslipidemia Drug Cards
Cardiology
43
Pharmacology
Graduate
09/02/2010

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Cards

Term
Lovastatin
Definition
Mevacor, Altoprev
Term
Pravastatin
Definition
Pravachol
Term
Simvastatin
Definition
Zocor
Term
Fluvastatin
Definition
Lescol
Term
Atorvastatin
Definition
Lipitor
Term
Rosuvastatin
Definition
Crestor
Term
Pitavastatin
Definition
Livalo
Term
Statin Side Effects
Definition
-Myopathy
-Increased liver enzymes
Term
Statin Contraindications
Definition
Absolute: liver disease
Relative: use with certain drugs (P450)
Pregnancy (women wanting to get preg should be removed off of statins 6-12 months in advance)
Term
4 Statins with least drug-drug interactions
Definition
-Pravastatin
-Fluvastatin
-Rosuvastatin
-Pitavastatin
Term
Bile Acid Sequestrants
Definition
-Cholestyramine
-Colestipol
-Colesevelam
Term
BAS Side effects
Definition
-GI distress
-Constipation
Term
BAS contraindications
Definition
Raised TG (especially >400 mg/dL)
Term
BAS DDI
Definition
Increases levels of:
Digoxin, Warfarin, Thyroxine, and Thiazides
Term
Nicotinic Acid Side effects
Definition
Flushing, hyperglycemia, hyperuricemia, upper GI distress, hepatoxicity
Term
Nicotinic Acid Contraindications
Definition
Liver disease (use w/ caution), severe gout, peptic ulcer, uncontrolled diabetes
Term
Nicotinic Acid
Definition
First line agent or an alternative for tx of Hypertriglyceridemia and Diabetic hyperlipidemia.
Term
Nicotinic Acid: cutaneous flushing and itching
Definition
Appears to be prostaglandin mediated and can be reduced by aspirin 325mg given 30 mins before Niacin ingestion.
Term
Niacin & Statins Combo
Definition
Produces large reductions in LDL and increases in HDL.
Term
Niacin associated Hepatitis
Definition
More common wtih sustained release preparations.
Term
Fibric Acids
Definition
-Gemfibrozil
-Fenofibrate
-Fenofibric Acid
Term
Fibric Acid Side effects
Definition
dyspepsia, gallstones, myopathy (slight myopathy)
Term
Fibric Acid Contraindications
Definition
Severe renal or hepatic disease
Term
Fenofibric Acid and Statins COMBO
Definition
Reduces TG levels and increases HDL levels in pt with mixed dyslipidemia and CHD or a CHD equivalent.
Term
Ezetimibe
Definition
Zetia
Term
Ezetimibe Facts
Definition
Lowers LDL, May raise HDL, Doesnt have anything to do with TG
Term
Ezetimibe Contraindications
Definition
-Hypersensitivity
-Pts with active liver disease or unexplained persistent elevations in serum transaminases (AST, ALT)
-Pregnant and nursing women
Term
Ezetimibe Administration
Definition
With or without food
Term
Lovaza (Fish Oil)
Definition
Omega-3 fatty acids
-EPA
-DHA

Approved by FDA for the tx of high triglyceride levels

NOT used as monotherapy, ,ALWAYS used as adjunctive therapy.
Term
Lovaza (fish oil) Side effects
Definition
GI (burping, taste perversion, dyspepsia)
Term
Advicor
Definition
Niacin ER + Lovastatin
Term
Caduet
Definition
Atorvastatin + Amlodipine
Term
Pravigard
Definition
Pravastatin + ASA
Term
Vytorin
Definition
Simvastatin + Ezetimibe
Term
Simcor
Definition
Simvastatin + Niaspan
Term
Statins Monitoring Parameters
Definition
Baseline: Lipids, LFT's, CPK

Test @ 6wk: Lipids, LFT's

Maintenance: Lipids and LFT's
Term
Niacin Monitoring Parameters
Definition
Baseline: Lipids, LFT's, Glucose

Test @ 6wk: Lipids, LFT's, Glucose

Maintenance: Lipids and LFT's
Term
Fibrates Monitoring Parameters
Definition
Baseline: Lipids, LFT's, CBC

Test @ 6wk: Lipids, LFT's, CBC

Maintenance: Lipid and LFT's, CBC
Term
BAS Monitoring Parameters
Definition
Baseline: Lipids

Test @ 6wk: Lipids

Maintenance: Lipids
Term
Simvastatin with Fibrates & Nictonic Acid
Definition
Lower the dose of Simvastatin (max dose should be 10mg of Simvastatin when using with these drugs)
Term
Simvastatin with Amiodarone or Verapamil
Definition
Max dose of Simvastatin is 20mg when used with these drugs.
Term
Rosuvastatin with Fibrates and Nicotinic Acid
Definition
Lower dose of rosuvastatin when using fibrates and nicotinic acid, EXCEPT for fenofibrate (Tricor)
Term
CHD risk equivalents
Definition
-Clinical CHD
-Symptomatic carotid artery disease
-Peripheral arterial disease
-Abdominal aortic aneurysm
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