Shared Flashcard Set

Details

drugs used in hyperlipdeima
drugs used in hyperlipiedmia
24
Medical
Graduate
12/05/2011

Additional Medical Flashcards

 


 

Cards

Term
familia hypechoelsteromeia
Definition
defects in ldl receptors dont endocyotse ldl so it accumulates
Term
ldl uptake and choelsterol homeostasis
Definition
when lots of ldl gets uptaken, hmg coa reducatse goes down, Acat- for choelsterol esterifcaiton goes up, and ldl receptors go down . - so uptake is also decreased .
Term
the choelstero lcircuit
Definition
ldl comesi nto cell via recetpors, hmg coa makes choelsetero land ldl is made to choelsterol , choelstero lthen ameks bile acids. Bileaacid depletion upregulates HMG COA and LDL receptor uptake to create mroe bile acids. Adding a reductase inhbiitor further upregulates the ldl re ceptor pathway
Term
Statins moa
Definition
hmg-coa reductase competitive inhibitors. inhibition of mevaolinic acid formation.
Term
Statins effects/uses
Definition
inhibits choelsterolgenesis. Ireased expression fo ldl receptor and icnreased removal of ldl form blood.

decresed heptaic vldl

can be used in kids with fmailal hhperchoelserolemia
Term
statisn pharmacokinetics
Definition
short halflifes <4 hours. cleared by CYP
Term
statin contraindication
Definition
women who have pregnant, lactating. dont want ot mess up fetuss ability to develop choelsterol.
Term
atorvastatin
Definition
most efficaous agent for sever hyperchoelsterolemia . mor tg lwoering acvitivy comapredi wth other statins
Term
rosuvastatin
Definition
most efficaous agent for sever hyperchoelsterolemia . mor tg lwoering acvitivy comapredi wth other statins
Term
statins adverse effects/toxiccity
Definition
elevated ALT levels.

Myopathies- flulike symtpoms- however can leed to rhabdomyolysis -> myoglobinuria-> renal failure and death

cyp3a4 metabolism and contraidnication.

TC genotype is intermediate for myopathies nad CC genotype is very high risk for myopathies due to decreased clearance from plasma
Term
bile acid sequesterants
Definition
posivel charged polymers, physically bind bile acids. Inhibit reabosrption, you get increaased syntehsis and secretion. you shoudl cadmisnter with statin, to that hmg coa doenst jsut coregulate.

leads to increase in hetapic tg synthesis
Term
resis therapuetic uses
Definition
take with meals or wont have any effect. for patients with bile salt accumulation, and removal of certain drugs from gut
Term
resins adverse effects
Definition
constipation bloating, heartburn adn diarrhea. rare malabospriton of vitamin k (hypporhtimbenamia). malabsorp of folic acidc, and incrased TG syntehsis
Term
resin interactions
Definition
binds lots of drugs, so make sure to take a certin amoutn of time after resins
Term
Niacin
Definition
best agent for icnreasing hdl, lowers triglicerides and ldl as well
Term
Niacin effect
Definition
resutls in decreased mobilziationof ffa into liver. , leading to reduced vldl secrtion.
Term
niacin pharacokinetics
Definition
rapidly absorbed.
Term
niacin toxicity/adverseeffects
Definition
hepatoxicity. concurent usei wth statin can cause myopathy.

cutaneos vasodilation.
hyperuricemia nad precipiate gout.

blunt th response to insulin. - diabetics.

teratogenic
Term
fibrates moa
Definition
pparalpha activation, which regulates enes that contorl lipid metabolism . Primary effect to reduce plasma TG. litle effect on LDl, sometimes even conversion to ad icreasa.e
Term
fibrates pharmacokientnics
Definition
gemfibrozil coresses placenta. Excretion impariedi n reinal failure. Also excretion impaired in liver
Term
fibrates adverse effects
Definition
highly plasma protein bound can dispalce other drugs such as anticoagulatns poetntiating their action.
Myopathy risk on statins (gemfiborizl). Increased choelsterol content of blodo and modesti ncrease of gal lstones. Contraidncaiton wtih renail fialure and hepatic dysfunciton. SHould nto be used bychildren or pregnatn women
Term
Ezetimibe MOA
Definition
slelctively inhibitsi ntestinal choelsteraol absorption. Target is NPCL1 transport protein in enterocytes. This decreases intestinal delivery of choelsterol to the liver. Increases expression of Heptaic LDL receptors.
Term
ezetabmibe circulation
Definition
circulates enteroheptaically, which limits sytemic exposure
Term
ezetamibime metabolism
Definition
possible elvation fo liver enzymes, glucoronidated.
Supporting users have an ad free experience!