Cholinergic synthesis/release

inhibit release of ACh into synapse

treat eye alignment issues

Cholinesterase inhibitor

Prevent CHe from breaking down choline and acetate

Keep ACh in synapse; constricts pupils

lasts on receptor for 10 min

Cholinesterase inhibitor

Prevent ChE from breaking ACh down to choline and esterase

Keeps ACh in synapse

lasts on receptor for 2-4 hours, glacoma

Acetylcholine

Muscarinic agonists

binds to nChR and mChR

constricts pupils

Muscarine Agonist

binds to mChR on postsynaptic cell

consticts pupils

Muscarine Antagonist

antagonist at mChR on postsynaptic cell

mydriatic and cycloplegic

Muscarine Antagonist

antagonist at mChR on postsynaptic cell

consticts pupils

Nicotinic Agonits

binds to nChR on postsynaptic cell

alertness, muscle contraction

Nicotinic Agonist

binds to nChR at NMJ

muscle contraction

Nicotinic/Ganglionic Blocker

Antagonist at nChR at NMJ

Relax skeletal muscle

Trimethaphan

Nicotinic/Ganglionic Blockers

Antagonist at nChR on ganglia

relieve hypertensive emergencies

block Ach both sym/para neurotransmitters

Phosphorylated ChE reactivator

ACh can be removed from synapse

Sympathomimetics

Directly Acting Agonist

increase SNS activity

Sympathomimetics

α₁ selective agonist

contractions of radial muscle, dialate pupils

Sympathomimetics

β₁ selective agonist

increase HR and force of contraction

Sympathomimetics

β₂ selective agoinst

smooth muscle relaxation

Sympathomimetics

nonselective, indireclty acting

facilitate NE release, dialate pupils

Sympathomimetics

blocks NE reuptake by NET

keeps NE in synapse longer, pupil dilation

Sympatholytics

α₂ selective blocker

prevent reuptake of NE into cell

Sympatholytics

α-blockers, nonselective

prevent NE from binding to receptor

Sympatholytics

α₁ selective blocker

prevent NE from binding to receptor

Sympatholytic

β-blocker, nonselective

prevent NE from binding to receptor

Sympatholytics

β-blocker, nonselective

prevent NE from binding to receptor

Sympatholytics

β₁-blocker

prevent NE from binding to receptor

Sympatholytic

Combined α₁ and β blocker

prevent NE from binding to receptor

Sypatholytic

reduce central symp outflow, actives α₂

negative feedback, decrease NE release

acts directly

Local anesthetic

ester group- PABA, prevent generation/conduction of berve impulses, reduce sodium permeability, reduce rate of rise of AP

loosens epithelium of cornea, reduces reflexive tears

local anesthetic

amide group - benzoic acid, same action as ester group

used in minor sugeries and spinal anesthia

IV anesthetic

intravenous

induction of maintaince of unconcieousness

Sympatholytics

β₁ blocker selective

Sympatholytics

reduce central symp outflow

negative feedback, decrease NE release

Sympatholitic

α₁ selective blocker

Cholinesterase inhibitor

prevents ChE from breaking down into choline and acetate

keeps ACh in synapse; constricts pupils

Muscarinic Antagonists

antagonista at mChR on postsynaptic cell

mydriatic and cycloplegic

Muscarinic Agonist

binds to mChR on postsynaptic cell

constrict pupils

Propofol

Etomidate

Katamine

Thiopental

Methohexital

Sevoflurane

Halothane

nitrous oxide

Diazepam

Midazolam

Benzo-

preoperative meds to calm patients

Fentanyl

Morphine

Opioid

Decrease anxiety, nausea; increase comfort