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Drug Selectivity
PHAR340
18
Pharmacology
Undergraduate 3
12/05/2012

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Cards

Term
Trimethoprim
Definition
Dihydrofolate reductase inhibitor is most effective in E. coli
Term
Pyrimethamine
Definition
Dihydrofolate reductase inhibitor is most effective in plasmodium
Term
Digoxin
Structure?
Definition
Multiple carbohydrate sugars enhance absorption
Term
L-norepinephrine
Definition
Active
Term
D-norepinephrine
Definition
Inactive
Term
Levorphanol
Definition
Antitussive and analgesic
Term
Dextromethorphan
Definition
Antitussive
No stimulation of morphine receptors - absence of CNS activity
Term
Norepinephrine
Structure? Adrenergic activity?
Definition
ɑβ1
Primary amine
Term
Epinephrine
Structure? Adrenergic activity?
Definition
ɑβ1β2
Secondary amine
Term
Isopropyl norepinephrine
Structure? Adrenergic activity?
Definition
β1β2
Tertiary amine
Term
Acetylcholine
Definition
Agonist at nicotinic and muscarinic receptors
Short acting
Term
Methacholine
Structure?
Definition
Favours muscarinic receptors
Longer acting due to steric hindrance of additional methyl group
Term
Muscarine
Structure?
Definition
One ring system
Agonist at muscarinic receptors
Term
Atropine
Structure?
Definition
Two ring system → molecular rigidity
Antagonist at muscarinic receptors
Term
Physostigmine
Definition
Tertiary amine, uncharged
CNS activity
Term
Neostigmine
Definition
Quaternary amine, charged
Term
Procaine
Definition
Ester, susceptible to esterases
Short-acting
Term
Procainamide
Definition
Amide
Longer-acting
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