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Dosing for Aminoglycosides
Some basic cards on parameters for AG dosing
6
Pharmacology
Graduate
04/11/2011

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Cards

Term
What are the exclusions for extended interval dosing for AGs?
Definition
Cystic fibrosis
Gram-positive synergy (including endocarditis)
Pregnancy
Acute burn injury (<48h since thermal injury)
Dialysis
Unstable renal function
Mycobacterial infections
Term
What is the Hartford Nomogram?
Definition
7mg/kg of gentamycin/tobramycin
Term
What are the initial dosing intervals for the Hartford nomogram?
Definition
CrCl > 60 = 24h
CrCl 40-59 = 36h
CrCl 20-39 = 48h
CrCl <20 = give as needed (trough less than 1)
Term
What is the Vd of AGs?
Definition
0.26L/kg
0.35L/kg for cystic fibrosis
Term
What is the Vd of AGs when the patient has cystic fibrosis?
Definition
0.35L/kg
Term
When dosing AG, what do you use for body weight?
Definition
For CrCl, if BW is less than IBW, use ABW. Only use aBW if the patient is greater than 30% above IBW.
Use the same weight for Vd calculations.
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