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DNA Replication
For Molecular Biology
24
Biology
Graduate
05/13/2013

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Term
Epsilon (POL 3)
Definition
3' to 5' exonuclease activity
Term
Theta (POL 3)
Definition
Stimulates exonuclease activity
Term
Alpha (POL 3)
Definition
Polymerase Holoenzyme
Term
Gamma (POL 3)
Definition
Binds to ATP
Term
Delta (POL 3)
Definition
Opens Beta Clamp
Term
Delta Prime (POL 3)
Definition
Stimulates Clamp loader
Term
Psi (POL 3)
Definition
Binds Holoenzyme to ssDNA
Term
Chi (POL 3)
Definition
Interacts with SSB - allows for removal of Dna G (Primace)
Term
Beta (POL 3)
Definition
Binds Dna Polymerase to Dna Strand
Term
Tau (POL 3)
Definition
Dimerizes Core; Activates Dna B helicase activity
Term
oriC
Definition
DNA Strand with 9bp region and 13 bp region. 9bp region wraps around Dna A complex to initiate replication fork
Term
SSB Proteins
Definition
Single Strand Binding Proteins. Bind at replication fork (both strands) to prevent re-annealing of the template DNA
(PROK)
Requires ATP
Term
DNA B
Definition
Helicase Enzyme responsible for growing replication fork
(PROK)
Term
DNA C
Definition
Part of DNA B-C complex which loads helicase onto replication fork. Dissociates after loading DNA B. (PROK)
Term
DNA G
Definition
Primase Enzyme responsible for synthesizing 11(+/-) 1 nt RNA primer which initiates synthesis for DNA Polymerase. Interacts with DNA B (connection is not fully understood) (PROK)
Term
DNA POL 3
Definition
Synthesizes leading strand DNA as well as Okazaki fragment DNA. (PROK)
Term
DNA POL 1
Definition
Synthesizes DNA to connect Okazaki Fragments. Removes RNA primers on lagging strand. (PROK)
Term
T antigen
Definition
viral encoded helicas (EUK)
Term
RPA
Definition
Replication protein A - SSB equivalent. (EUK)
Term
RPC
Definition
Replication Protein C - Clamp loader. (EUK)
Term
Polymerase alpha
Definition
Primase equivalent (EUK)
Term
PCNA
Definition
Proliferating Cell Nuclear Antigen (trimer which acts as a sliding clamp) (EUK)
Term
Polymerase Delta
Definition
Primary leading strand polymerase. (EUK)
Term
Polymerase Epsilon
Definition
Primary Polymerace for leading strand in YEAST (EUK)
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