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DIURECTICS
YEP
9
Medical
Graduate
01/19/2013

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Cards

Term
Acetazolamine
Definition
Proximal Tubule Carbonic Anhydrase Inhibitor

Prevents resorbtion Na/HCO3 but renal compensation reduces effect

TX = Glaucoma, Epilepsy, Altitude sickness

Interacts with amphetamines by increasing urine pH

Can Cause metabolic acidosis
Can have allergic rxn similar to sulfide and deplete bone marrow
Term
Furosemide
Definition
Loop diuretic in thick ascending limb inhibits Na/k/Cl cotransport and has a slight decrease on mg/ca2+

profound diuretcs, can cause
Hyponatremia, hypokalemia
hyperuremia, hyperglycemia

Tx hypercalcemia also

OTOXIC and hypersensivity due to similarity to sulfonimides
Term
Chlorthidone
Definition
Chlorthiadone t1/2> hydrochlorthiazide

# 1 drug hypertension

Ceiling diuretics that block Na/Cl symporters.

Can cause HYPERCALCEMIA, hypokalemia, hyponatremia, hyperuremia, hyperglycemia

NSAIDS BLUNT

hypersensitivity reactions
Term
amiloride
Definition
K sparing diuretic via Na channel blocker
Term
spirolactone
Definition
aldosterone receptor antagonists

cause gynocomastia,decrease libido, mess with menstratioin, cause impotense, increase hairgrowth

collecting duct
Term
Mannitol
Definition
Osmotic Diuretic used to maintain patency of renal arteries

avoid in patients with heart problems because increases intravascular volume load.
Term
triamterene
Definition
K sparing diuretic via Na channel blocker
toxicity = hyperkalemia
Term
eplerenone
Definition
aldosterone receptor antagonists

ause gynocomastia,decrease libido, mess with menstratioin, cause impotense, increase hairgrowth

HYPERKALEMIA
Term
hydrochlorthiazide
Definition
Chlorthiadone t1/2> hydrochlorthiazide

# 1 drug hypertension

Ceiling diuretics that block Na/Cl symporters.

Can cause HYPERCALCEMIA, hypokalemia, hyponatremia, hyperuremia, hyperglycemia hypo magnisia

NSAIDS BLUNT

hypersensitivity reactions, increases lithium concentration
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