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Disease Process
Immunity/Infective Disorders
22
Nursing
Undergraduate 2
11/18/2010

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Cards

Term
Purpose of Inflammation & Immunity
Definition
To meet human need for protection by neutralizing, eliminating, or destroying organisms that invade the internal environment.
Term
Human Leukocyte Antigens
Definition
Unique universal product code for each person.
Present on surface of nearly ALL body cells.
Act as antigens only if enter another person's body.
Term
Organization of the Immune System (Bone Marrow)
Definition
Source of all blood cells, including immune system cells.
Produces stem cells.
Term
Stem Cells
Definition
Immature undifferentiated cells.
Pluripotent (each cell has more than 1 potential outcome).
Pathway depends on body needs & presence of growth factors.
Term
Leukocytes (WBCs)
Definition
Protect body from effects of invasion by organisms. (Knights & Soldiers protecting the castle)
Term
WBC defensive actions
Definition
1. Recognition of self vs non-self
2. Destruction of foreign invaders, cellular debris, & unhealthy or abnormal self cells.
3. Production of antibodies directed against invaders
4. Complement activation.
5. Production of cytokines that stimulate increased formation of leukocytes in bone marrow & increase specific leukocyte activity
Term
Leukocytes involved in inflammation
Definition
Neutrophil
Macrophage
Monocyte
Eosinophil
Basophil
Term
Neutrophil Inflammation Fx
Definition
Nonspecific ingestion & phagocytosis of microorganisms & foreign protein
Term
Macrophage Inflammation Fx
Definition
Nonspecific recognition of foreign proteins & microorganisms; ingestion & phagocytosis
Term
Monocyte Inflammation Fx
Definition
Destruction of bacteria & cellular debris; matures into macrophage.
Term
Eosinophil Inflammation Fx
Definition
Weak phagocytic action; releases vasoactive amines during allergic reactions.
Term
Basophil Inflammation Fx
Definition
Releases histamine & heparin in areas of tissue damage.
Term
Leukocytes involved in Antibody-Mediated Immunity
Definition
B-lymphocyte
Plasma cell
Memory cell
Term
B-lymphocyte Immunity Fx
Definition
Becomes sensitized to foreign cells & proteins.
Term
Plasma Cell Immunity Fx
Definition
Secretes immunoglobulins in response to the presence of a specific antigen.
Term
Plasma Cell Immunity Fx
Definition
Secretes immunoglobulins in response to the presence of a specific antigen.
Term
Memory Cell Immunity Fx
Definition
Remains sensitized to a specific antigen & can secrete increased amounts of immunoglobulins specific to the antigen on re-exposure.
Term
Lymphocytes Involved in Cell-Mediated Immunity
Definition
T-lymphocyte helper/inducer T-cell
Cytotoxic/cytologic T-cell
Natural killer cell
Term
T-lymphocyte helper/inducer T-cell Immunity Fx
Definition
Enhances immune activity through secretion of various factors, cytokines, & lymphokines.
Term
Cytotoxic/cytolytic T-cell Immunity Fx
Definition
Selectively attacks & destroys non-self cells, including virally infected cells, grafts, & transplanted organs.
Term
Natural Killer Cell Immunity Fx
Definition
Nonselectively attacks non-self cells, especially body cells that have undergone mutation & become malignant; also attacks grafts & transplanted organs.
Term
Difference b/t Inflammation & Immunity
Definition
1. Provides immediate b/ short-term against injury or invading organism. It doesn't provide true immunity on repeated exposure to the same organisms.
2. Inflammation is a NONSPECIFIC body defense to invasion or injury & can be statred quickly by almost any event, regardless of where it occurs or what it causes.
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