Shared Flashcard Set

Details

Digestive 9
Vitamin/Mineral Absorption
22
Veterinary Medicine
Not Applicable
04/08/2017

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Cards

Term
True or False

The majority of calcium ingested, passes through the GIT unabsorbed
Definition
true
Term
True or False

Calcium diffuses readily down its concentration gradient
Definition
false, its not very good at it
Term
Absorption of calcium via diffusion is (independent/dependent) on calcium
Definition
independent
Term
Vitamin D dependent absorption of calcium occurs in the...
Definition
duodenum
Term
What carrier molecule binds to calcium for transport via active pumping?
Definition
calbindin
Term
True or False

Phosphorous diffuses readily down its concentration gradient
Definition
true (but it's absorbed in phosphate form)
Term
How does Vit D influence phosphate absorption?
Definition
low-P diet will cause vit D to promote absorption by increasing expression of Na/PO4 symporters
Term
How is iron absorbed?
Definition
-via receptors for protein-bound iron (e.g. heme, lactoferrin)

-via DMT-1 transporter (Fe/H+ symporter)
Term
What is ferritin?
Definition
storage site for iron as Fe3+, will release it into blood as needed
Term
Iron is transported through the blood via...
Definition
transferrin
Term
True or False

There is no specific mechanism for
iron excretion
Definition
true
Term
What does hepcidin do?
Definition
secreted by liver when iron stores are high, it reduces iron absorption in the gut
Term
What do you measure to estimate iron levels in the body?
Definition
transferrin levels in plasma
Term
When is Vit C required for iron absorption?
Definition
when it is bound to ferritin or hemochrome (eggs and veggies)

NOT required for heme-bound iron (meat)
Term
Why is it important to balance Cu & Zn in the diet?
Definition
they compete for the same carrier
Term
Fat soluble vitamins are absorbed via (active/passive) diffusion
Definition
passive
Term
Vit C is absorbed via...
Definition
Na/ Vit C symporter
Term
Vit B6 is absorbed via...
Definition
passive diffusion
Term
Vit B12 is absorbed via...
Definition
binding of B12 to intrinsic factor, then binding to ileal enterocytes
Term
Vit B12 binds to intrinsic factor in the....
Definition
duodenum
Term
B12/intrinsic factor complex is is absorbed in the...
Definition
ileum
Term
Why might exocrine pancreatic insufficiency lead to a B12 deficiency?
Definition
pancreas produces intrinsic factor which is required for B12 absorption (applies to carnivores only - herbivore bacteria produce their own)
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