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dermpath
random
34
Medical
Graduate
10/23/2011

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Cards

Term
how would you classify p.foliaceus?
Definition
Term
subcorneal acantholytic blistering disease
Definition
Term

what are other disorder causes the same split?

 

Definition
Term
Staphylococcal scalded skin syndrome
Definition
Term
which inflammatory cells are *** in p. foliaceus?
Definition
Term

eosinophils are characteristic in p. foliaceus

 

Neutrophils can also be seen

Definition
Term

which other condition can p. foliaceus mimic?

 

Definition
Term

bullous impetigo - this can occur if p. foliaceus get impetiginized

 

IMPETIGINIZED CRUST DOES NOT R/O P. FOLIACEUS

Definition
Term

What is the underlying cause of p. foliaceus?

 

Definition
Term
autoantibodies directed against desmoglein 1 (160 kD)
Definition
Term
what is desmoglein 1?
Definition
Term

desmoglein 1 is an intercellular (transmembrane) keratinocyte adhesion glycoprotein in association with desmosomes

 

Definition
Term
what is the difference between desmoglein and desmoplakin?
Definition
Term

desmoplakin is intracellular


desmoglein is transmembrane

 

 

Definition
Term
describe the DIF of p. foliaceus
Definition
Term

DIF of p. foliaceus:

 

considered diagnostic. INTERCELLUAR immunofluorescence of IgG and C3 deposits confined to the UPPER HALF of the epidermis

 

described as a NET-LIKE pattern

Definition
Term
where does the split occur in p. foliaceus?
Definition
Term
split occurs in the granular layer in p. foliaceus
Definition
Term
what is pemphigus erythematosus?
Definition
Term

p. erythematosus is a condition that the immunohistologic findings are between p. foliaceus and lupus erythematosus:

 

1. ANA antibody

 

2. DIF shows intercellular deposition AND "lupus band" along basement membrane

Definition
Term
summarize the key features of p. foliaceus
Definition
Term

key features of p. foliaceus:

  • subcorneal split
  • acantholysis 
  • dyskeratosis in the granular layer
  • DIF net-like pattern of IgG and C3 between keratinocytes of the upper epidermis
  • eosinophils around BVs and in epidermis
  • spongiosis 
Definition
Term
what conditions cause spongiosis with epidermal eosinophils?
Definition
Term
eosinophilic spongiosis = HAAPPIEES
  1. Herpes gestationis
  2. Arthopod bite reaction
  3. Allergic contact
  4. Pemphigus foliaceus
  5. Pemphigoid
  6. Incontinentia pigmenti
  7. Erythema toxicum (spongiosis ajacent to hair follicle)
  8. EBA
  9. Scabies
Definition
Term
what is another name for Grover's disease?
Definition
Term

transient acantholytic dyskeratosis (TAD)

 

persistent acantholytic dermatosis (PAD)

 

TAD and PAD are groovey!!

Definition
Term
what is TAD or Grover's disease infamous for?
Definition
Term

TAD can mimic Darier's disease and Hailey-Hailey and pemphigus!

 

All of these histo features can be seen in the SAME specimen!!

Definition
Term
since Grover's disease is sooo GROOVEY, how can you pin the diagnosis down?
Definition
Term

grover's disease can be diagnosed by:

  • clinical appearance: focal lesions
  • histo: many patterns are seen in the same biopsy clues you in that it's groovey Grover!!
  • eosinophils: if present, r/o Darier's
  • DIF:  negative cf. to pemphigus
Definition
Term
how would you define Grover's disease?
Definition
Term
Grover's disease is an acquired, pruritic, self-limiting, acantholytic disease of unknown etiology of middle aged to elderly
Definition
Term
where on the body does Grover's disease typically occur? 
Definition
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