Shared Flashcard Set

Details

Cytokines
N/A
19
Medical
Professional
08/30/2009

Additional Medical Flashcards

 


 

Cards

Term
IL-1
Definition

monocytes, mΦ, DCs, Ts, Bs, NKs, vascular epithelium

 

  • fever, acute phase response, stimulation of neutrophil production
Term
IL-2
Definition

Ts

 

  • stimulates growth and differentiation of Ts, Bs, and NKs
Term
IL-4
Definition

mast cells, Ts, bone marrow stromal cells

 

  • growth and development of Bs and Ts
  • TH2 differentiation
  • class switch to IgE
Term
IL-5
Definition

mast cells, Ts, eosinophils

 

  • induces eosinophil formation and differentiation
Term
IL-6
Definition

Ts, Bs, mΦ,bm stromal cells

 

  • along with TNFβ, promotes TH17 development
  • proinflammatory cytokine produced by TH17s
Term
IL-7
Definition

bm stromal cells, thymic stromal cells, spleen cells

 

  • growth factor for T and B cell progenitors
  • receptor mutation leads to X-linked SCID
Term
IL-8
Definition

monocytes, lymphocytes, granulocytes

 

  • chemoattractant and activator of neutrophils
  • also attracts basophils and some subpopulations of lymphocytes
  • has angiogenic activity
Term
IL-10
Definition

activated subsets of CD4+ or CD8+ Ts

 

  • produced by Tregs to negatively regulate immune responses
  • in cooperation with TGF-β, stimulates IgA synthesis and secretion by Bs
  • antagonizes generation of TH1s
Term
IL-12
Definition

mΦ and DCs

 

  • induces differentiation of TH1a
  • induces IFN-γ production by Ts and NKs and enhances NK activity
Term
IL-17
Definition

TH17

 

  • proinflammatory cytokine produced by TH17
Term
G-CSF
Definition

bm stromal cells and mΦ

 

  • essential for growth and differentiation of neutrophils
Term
GM-CSF
Definition

Ts, mΦ, fibroblasts, endothelial cells

 

  • growth factor for hematopoietic cells and differentiation factor for granulocyte and monocyte lineages
Term
M-CSF
Definition

lymphocytes, monocytes, fibroblasts, epithelial cells, + others

 

  • growth, differentiation, surrvival factor for mΦ progenitors and mΦ
Term
IFN-α/IFN-β
Definition

lymphocytes, DC, mΦ, fibroblasts

 

  • induces resistance to viruses and inhibits cell proliferation
  • regulates expression of MHC I
Term
IFN-γ
Definition

CD4+, CD8+ Ts, NKs

 

  • affects activation, growth, and differentiation of Ts, Bs, mΦ, and NKs
  • up-regs MHC expression on APCs
  • signature cytokine of TH1 differentiation
  • weak anti-viral and anti-proliferative properties
  • stimulates class switch to IgG2a
Term
TNF-α
Definition

monocytes, mΦ, activated Ts, NKs, neutrophils, fibroblasts

 

  • strong pro-inflammatory mediatory
  • promotes angiogenesis, bone resorption, and thrombotic processes
Term
TGF-β
Definition

activated Ts, Bs,

 

  • stimulates class switch to IgA
  • protomtes Treg development
  • along with IL-6, induces TH17 differentiation
  • anti-angiogenic
  • induces terminal differentiation of monocytes
  • stimulates neutrophil production of ROS, increases phagocytosis and enhances adhesion
Term
RANTES
Definition

Ts, eosinophils, basophils, monocytes

 

  • Attracts T cells, eosinophils, and basophils to inflammatory sites
Term
EGF, bFGF, PDGF, VEGF
Definition

 

 

  • promote wound healing and angiogenesis
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