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CVT Anticoagulants Dosages
CVT Anticoagulants Dosages
13
Pharmacology
Professional
08/31/2012

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Cards

Term
Sodium Heparin
Definition
•50 u/kg
•For acute myocardial infarction (AMI) 5000u loading and 1000 u/hr
Term
ReoPro (Abciximab)
Definition
•.25 mg/kg bolus
•Then .125 mcg/kg/min for MI
•For PCI post, 10 mcg/kg/min for 12 hours
Term
Tirofiban HCL (Aggrastat)
Definition
•Initial dose of 0.4 mcg/kg/min for 30 minutes
•Followed by 0.1 mcg/kg/min for 48 to 108 hours or 12 – 24 hours after coronary intervention
Term
Bivalirudin (Angiomax)
Definition
•Initially, 1 mg/kg IV bolus just before PCI
•Infusion at 2.5 mg/kg/hr for 4 hours
•Administer another IV infusion at 0.2 mg/kg/hr for up to 30 hours as needed
•Store prepared solution for up to 24 hours at 36 to 46 degrees Fahrenheit
•Give with 325 mg of aspirin
Term
Argatroban (Acova)
Definition
•Begin infusion of 25 mcg/kg/min and administer bolus dose of 350 mcg/kg (over 3 to 5 minutes)
•ACT should be checked 5 to 10 minutes after bolus
•Proceed with procedure if ACT is > 300 seconds
•ACT < 300 seconds: give an additional 150 mcg/kg bolus and increase infusion rate to 30 mcg/kg/min (recheck ACT in 5 to 10 minutes)
•ACT > 450 seconds: decrease infusion rate to 15 mcg/kg/min (recheck ACT in 5 to 10 minutes)
•Once at therapeutic ACT (300 to 450 seconds), infusion should be continued at this dose for the duration of the procedure
•Reduce dosage to 0.5 mcg/kg/min in hepatic impairment
•Impending abrupt closure, thrombus formation during PCI, or inability to achieve ACT > 300 seconds: an additional bolus of 150 mcg/kg, followed by an increase in infusion rate to 40 mcg/kg/min may be administered
Term
Integrilin (Eptifibatide)
Definition
•For MI 180 mcg/kg bolus then 2 mcg/kg/min for 72 hours
•For PCI 135 mcg/kg bolus then .5 mcg/kg/min
Term
Lovenox (Enoxaparin)
Definition
•1 mg/kg BID with ASA for 2 - 8 days
Term
Protamine Sulfate
Definition
•1 mg neutralizes 100 units of heparin
•50 mg max in a 10 minute period
Term
Activase (tPA)
Definition
•Loading 6 - 10 mg over 1 - 2 min
•60 mg over the first hour
•Second and third hours 20 mg each
•Weight < 65 kg give 1.25 mg/kg over three hours
Term
Retavase
Definition
•10 units over 2 min
•Repeat 10 unit in thirty minutes
Term
Aspirin
Definition
•Analgesic/antipyretic: 325 - 650 mg PO q 4 hours as needed
•Acute MI: 325 mg (or 4 x 81 mg chewable tablets to facilitate sublingual absorption and to expedite antiplatelet activity)
•Thromboembolic disorders: 325 - 650 mg PO QD or BID
•MI prophylaxis: 81 - 325 mg PO QD
Term
Clopidogrel (Plavix)
Definition
•75 mg PO QD is recommended
•For ACS with or without PCI, load with 300 mg and then continue with 75 mg daily
Term
Enalapril (Vasotec)
Definition
•Hypertension
•PO: 5 mg/day; may increase to 10 to 40 mg/day in 1-2 divided doses
•IV: 1.25 mg slow IV push over 5 minutes every 6 hours; may give up to 5 mg every 6 hours in hypertensive emergencies
•CHF: 2.5 mg PO QD or BID; may increase up to 5 to 20 mg/day in 1 to 2 divided doses (max of 40 mg/day
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