Shared Flashcard Set

Details

Constipation UCSF
Lecture 11/14/12
124
Pharmacology
Graduate
11/14/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Define Constipation.
Definition

Change in bowel movement characterized by infrequent and difficult passage of stool.

 

Term
List 5 factors that increase your risk of getting constipation (risk factors).
Definition
  1. Woman (women > men).
  2. Greater than 65 years of age.
  3. Infant and children.
  4. Pregnancy.
  5. Low-income.
Term
How does fecal matter move from the sigmoid colon to the rectum?
Definition
Mass peristaltic movement (after spending 2 hours in the stomach).
Term
List 3 physiological reactions to fecal matter in the rectum.
Definition
  1. Desire to defecate.
  2. Relaxation of internal anal sphincter.
  3. Tightening of abdominal wall muscles.
Term
What is the normal physiology of having a bowel movement?
Definition

1. Valsalva maneuver forces stool down.

2. Voluntary relaxation of the external anal sphincter followed by elevation of the pelvic diaphragm.

3. Stool is expelled.

Term
What is the valsalva maneuver?
Definition
Attempting to forcibly exhale while keeping your mouth and nose closed.
Term
What is one way to "measure" constipation?
Definition
Bristol Stool Chart
Term
List the 7 types of stool in the Bristol Stool Chart.
Definition

1. Separate hard lumps, like nuts (hard to pass).

2. Sausage-shaped but lumpy.

3. Like a sausage but with cracks on the surface.

4. Like a sausage or snake, smooth and soft.

5. Soft blobs with clear cut edges (passed easily).

6. Fluffy pieces with ragged edges (mushy stool).

7. Watery, no solid pieces (entirely liquid).

Term
What two types of stool in the Bristol Stool Chart indicate constipation?
Definition
Type 1 and Type 2
Term
List some signs and symptoms of constipation.
Definition

* Hard, small, or dry stool ("pellet-like").

* Feeling of incomplete bowel evacuation after defecation.

* Straining or grunting.

* Sensation of blockage.

* Lack of urgency to evacuate.

* Bloating.

* Unproductive calls.

* Abdominal cramping/abdominal discomfort.

* Fatigue.

* Headache.

* Nausea and vomiting.

 

Term
List 5 general causes of constipation.
Definition

1. Lifestyle or extrinsic factors.

2. Structural.

3. Idiopathic.

4. Drug-induced.

5. Disease state.

Term
List 5 lifestyle or extrinsic factors that can cause constipation.
Definition

1. Insufficient dietary fiber.

2. Inadequate water intake.

3. Lack of exercise.

4. Poor bowel habits.

5. Avoiding the urge to defecate.

Term
List 2 structural factors that can cause constipation.
Definition
  1. Colorectal infury, inflammation, or damage.
  2. Impaired function of the pelvic floor.
  3. Structural abnormalities such as hernia, tumors, strictures.
Term
List 3 general ways that drugs can cause constipation.
Definition
  1. Decrease GI motility.
  2. Astringent actions.
  3. Decrease GI contractility.
Term
What 2 categories of drugs cause constipation by decreasing GI motility?
Definition
  1. Opioid analgesics.
  2. Anticholinergics.
Term
List 3 drugs that can cause constipation through astringent action.
Definition
  1. Aluminum.
  2. Calcium.
  3. Iron supplements.
Term
List one family of drugs that can cause constipation by decreasing GI contractility.
Definition

Calcium Channel Blockers

 

Term
Give one example of a Calcium Channel Blocker that causes constipation.
Definition
Verapamil
Term
List 5 "other" categories of drugs that can cause constipation.
Definition
  1. Diuretics.
  2. Antidiarrheals.
  3. Sedative hypnotics.
  4. Anxiolytics.
  5. Muscle relaxants.
Term
List 5 systemic disease states that can cause constipation.
Definition
  1. Hypothyroidism.
  2. Diabetes mellitus.
  3. Electrolyte abnormalities.
  4. Irritable bowel syndrome.
  5. Pituitary disorders.
Term
How does Diabetes mellitus cause constipation?
Definition
Some diabetic patients get peripheral neuropathy that can slow the gut.
Term
List 4 neurologic diseases that can cause constipation.
Definition
  1. Parkinsons.
  2. Dementia.
  3. Multiple sclerosis.
  4. Cerebrovascular accident (stroke).
Term
List 3 psychological disease states that can cause constipation.
Definition
  1. Depression.
  2. Eating disorders.
  3. Situational stress.
Term
Why would a patient with an eating disorder be at risk for constipation?
Definition
Many people with eating disorders abuse laxatives to help stay thin. If laxatives are used for a prolonged period of time, a rebound effect will occur when the person stops taking the laxatives.
Term
List 3 characteristics of acute constipation.
Definition
  1. Episodic.
  2. Usually less than 2 weeks.
  3. Lifestyle related.
Term
List 4 lifestyle related things that can cause acute constipation.
Definition
  1. Food intake.
  2. Change in environment.
  3. Low fiber intake.
  4. Dehydration.
  5. Lack of exercise.
Term
Define chronic constipation.
Definition
Constipation that continues over several weeks to months.
Term
List 2 causes of chronic constipation.
Definition
  1. Medical condition related (related to disease state).
  2. Medication related.
Term
Which type of constipation (acute or chronic) can you recommend OTC treatment.
Definition
Acute only! Chronic constipation should NOT be self-treated.
Term
What is the "Rome III criteria"?
Definition
The "gold standard" for defining chronic constipation.
Term
How would you define constipation following the Rome III criteria?
Definition
To define chronic constipation using the Rome III criteria, the patient must demonstrate at least 2 of the criteria for atleast 3 months in the previous 6 months.
Term
List the Rome III criteria.
Definition
  • Straining in 25% or more of bowel movements.
  • Lumpy or hard stools in 25% or more of bowel movements.
  • Sensation of incomplete evacuation in 25% or more of BM's.
  • Sensation of anorectal obstruction/blockade in 25% or more of BM's.
  • Manual maneuvers to facilitate defecation in 25% or more of BM's.
  • Less than 3 BM's per week.
  • Loose stool rarely present without use of laxatives.
Term
List 3 complications that can result from constipation (we want to prevent these in our patients!)
Definition

1. Hemorrhoids.

2. Rectal prolapse.

3. Blood pressure surges.

4. Fecal impaction.

Term
List 7 important points to ask the patient about when taking a medical history for constipation.
Definition

1. Sypmtom analysis.

2. Past medical history.

3. Medication history.

4. Social history.

5. Normal stool frequency.

6. Physical evaluation.

7. Past surgical history.

Term
What are 3 important points to ask about when taking a patient's social history specific for constipation?
Definition

1. Diet.

2. Fiber intake.

3. Fluid intake.

Term
List 6 exclusions from self-treatment. (Refer to physician if...!!)
Definition

1. Sharp, severe abdominal pain (7/10).

2. Nausea and/or vomiting.

3. Sudden change in bowel habits that persists for 2 weeks.

4. Use of laxative product for more than 7 days (unless directed to by their physician).

5. Occurence of rectal bleeding.

6. Lack of a bowel movement after laxative use at any time during treatment (discontinue OTC, and consult Dr).

Term
What are the 4 goals of therapy for constipation?
Definition

1. Identify and treat the underlying cause.

2. Relieve constipation.

3. Prevent straining and complications.

4. Prevent recurrence.

Term
What are 2 general non-pharmacological treatments for constipation that should always be recommended?
Definition

1. Dietary changes.

2. Lifestyle changes.

Term
What dietary changes can a patient do to help prevent future constipation episodes?
Definition

Increase dietary fiber (to 25-30g per day).

- Do this by eating brans, fruits, vegetables, nuts, and prunes.

Term
What lifestyle changes can a patient attempt to prevent constipation?
Definition
  • Maintain adequate hydration.
  • Increase exercise.
  • Bowel training
    • Go soon after waking in the morning.
    • Allow enough time, and never ignore the urge.
Term
List the 6 categories of OTC pharmacological treatments for constipation.
Definition

1. Bulk forming agents.

2. Emollients.

3. Lubricating agents.

4. Saline laxatives.

5. Hyperosmotic agents.

6. Stimulant laxatives.

Term
How long should an OTC laxative be used for?
Definition
1 week or less. If still needed after 1 week, consult your physician!
Term
What is the mechanism of action for bulk-forming agents?
Definition
Absorbs water to increase bulk, which stimulates peristalsis.
Term
How long do bulk-forming agents take to start working (produce a BM)?
Definition
12-24 hours (may take up to 72 hrs).
Term
List 3 bulk-forming agents, both brand name and generic.
Definition

1. psyllium (Metamucil).

2. methylcellulose (Citrucel).

3. calcium polycarbophil (FiberCon)

*4. wheat dextrin (Benefiber) -- Not FDA approved for constipation.

Term
What is the dose for bulk-forming agents?
Definition

Follow package instructions

(usu. 2-3g per day).

Term
What are the side effects of bulk-forming agents?
Definition
bloating, flatulence.
Term
List 2 precautions that should come to mind with bulk-forming agents.
Definition

1. Anaphylaxis if inhaled.

2. Esophageal obstruction -- FDA warning.

Term
What patients are at risk for esophageal obstruction when using bulk-forming agents?
Definition

1. Patients with difficulty swallowing or esophageal strictures.

2. Fluid restricted patients (heart failure, kidney disease).

3. Bed bound patients on opioids.

Term
List 4 advantages of bulk-forming agents.
Definition

1. Replaces missing fiber.

2. Safe for long-term use.

3. NOT absorbed systemically.

4. Considered "natural" by patients.

Term
What is the major disadvantage of bulk-forming agents?
Definition

*** Space all bulk-formers by 2 hours!! ***


polycarbophil (FiberCon) may decrease absorption of some Rx meds due to calcium chelation (tetracyclines, fluoroquinolones).

Term
List 3 counseling points you would want to tell your patient if they are purchasing a bulk-forming agent.
Definition

1. MUST stay hydrated!

2. If in powder form: Mix in 8 oz of water and drink immediately.

3. Separate from other medications by 2 hours.

Term
What is the mechanism of action for Emollients?
Definition

Anionic surfactant that reduced surface tension of the oil-water interface of stool which enhances incorporation of water and fat into the stool ("Mush")

aka- Stool softener

Term
What is the onset of action for Emollients?
Definition
24 to 72 hours (but may take up to 5 days)
Term
What is the dosing for Emollients?
Definition

100 - 250mg BID

Up to 500mg/day divided into 1 to 4 doses.

Term
What side effects are associated with Emollients?
Definition

Abdominal cramping

Diarrhea

Term
What is the generic and brand name of a common Emollient?
Definition

docusate sodium

Colace ®

Term
List 2 advantages of Emollients.
Definition

1. Not systemically absorbed.

2. Useful for preventing constipation.

Term
List two Disadvantages to Emollients.
Definition

1. May increase absorption of mineral oil!

2. Syrup tastes terrible.

Term
List some side effects associated with Emollient use.
Definition

Weakness, sweating, muscle cramps, arrhythmias (usually associated with higher than recommended doses).

Term
List 2 indications for Emollients.
Definition

1. Patients who need to avoid straining (surgery, postpartum, hemorrhoids, arrhythmia, severe hypertension).

2. Opiate-induced constipation (used with a stimulant laxative).

Term
What 2 patient counseling tips would you tell a patient taking an Emollient?
Definition

1. Take with a full glass of water, milk, or juice.

2. Stop if stools become loose.

Term
What is the mechanism of action of Lubricating Agents?
Definition
Decreases absorption of water in the colon and coats stools, resulting in ease of stool passage.
Term
What is the onset of action for Lubricating Agents?
Definition

Liquid: 6-8 hours.

Rectal enema: 5-15 minutes.

Term
What is the dosing regimen for lubricating agents?
Definition

5 - 45 mL PO daily.

118 mL PR (single dose).

Term
What side effects can be associated with lubricating agents?
Definition

1. Lipid pneumonia.

2. Anal leakage (and itching/irritation associated with large doses).

3. Abdominal cramps, diarrhea, nausea, vomiting.

Term
What patients are at risk for lipid pneumonia per FDA warning?
Definition

1. Children less than 6 years of age.

2. Geriatric patients.

3. Bedridden patients.

4. Patients with difficulty swallowing.

5. Pregnant patients.

Term
What is an advantage to lubricating agents?
Definition
Minimally absorbed.
Term
List 2 disadvantages to taking lubricating agents.
Definition

1. Avoid in pregnancy.

2. Hypersensitivity with repeated and prolonged use.

Term
Why should you avoid lubricating agents when pregnant?
Definition
Mineral oil impairs the absorption of fat-soluble vitamins (ADEK)
Term
List two precautions for lubricating agents.
Definition

1. Risk of asiration when taken orally.

2. Can NOT be taken with an Emollient.

Term
Why should you not take mineral oil with an Emollient?
Definition
Emollients increase the systemic absorption of mineral oil.
Term
List 5 patient counseling points to tell your patients who are taking mineral oil.
Definition

1. Remain upright when taking orally.

2. Do NOT take oral formulation before bed.

3. Take 2 hours before or after meals.

4. Impairs vitamin absorption, and increases systemic absorption of mineral oil.

5. Reduce dose if anal leakage occurs.

Term
What is the mechanism of action of Hyperosmotic agents?
Definition

Oral: Creates an osmotic gradient to draw water into the colon, causes distention and stimulates evacuation.

Rectal: Local irritant that stimulates lower bowel evacuation.

Term
What is the brand name and generic name of the oral hyperosmotic agent?
Definition

Polyethylene glycol (PEG)- 3350

MiraLax ®

Term
What is the brand and generic names for the rectal hyperosmotic agent?
Definition

Fleet suppository ®

glycerin

Term
What is the onset of action for hyperosmotic agents?
Definition

Oral: 24 to 72 hours.

Rectal: 15 to 30 minutes.

Term
What is the dosing for hyperosmotic agents?
Definition

Oral: 17g daily

Rectal: glycerin 3g daily.

Term
List a few side effects of hyperosmotic agents.
Definition

Rectal irritation.

Abdominal bloating/cramping.

Diarrhea.

Term
List 2 precautions for hyperosmotic agents.
Definition

Can cause rectal irritation.

Chronic use can lead to decreased serum potassium levels.

Term
List 3 advantages to using hyperosmotic agents to relieve constipation.
Definition

1. Minimal systemic absorption.

2. No DDI.

3. Useful in idiopathic constipation because safe!

4. Can mix with juice for kids!

Term
What are 2 patient counseling points for use of hyperosmotic agents?
Definition

1. Patients with renal disease should talk to Physician first.

2. Mix Miralax with 4-8 oz of water, juice, or soda.

Term
What is the mechanism of action of saline laxatives?
Definition

1. Ions draw water into the colon, resulting in an increase of intraluminal pressure and stimulates motility.

2. Magnesium stimulates secretion of cholecystokinin to stimulate bowel motility and fluid secretion.

Term
What is the onset of action for saline laxatives?
Definition

Oral: 30 min to 3 hours.

Rectal: 2 to 5 minutes.

Term
List two oral saline laxatives (brand name and generic).
Definition

1. magnesium hydroxide: Phillips' Milk of Magnesia ®

2. magnesium citrate: Evac-Q-Mag ®

Term
What is the brand name and generic name of a saline laxative?
Definition

sodium phosphate

Fleet Saline Enema ®

Term
What is the oral dosing for saline laxatives?
Definition
15-45 mL QD at bedtime or in divided doses.
Term
What is the dosing for rectal saline laxatives?
Definition
4.5 oz enema (1 bottle) as a single dose.
Term
What are some side effects of saline laxatives?
Definition

1. Fluid overload.

2. Hypermagnesemia.

3. Hyperphosphatemia.

Term
In what patient disease state would you see the side effects for saline laxatives?
Definition
Renal insufficiency.
Term
What are 4 precautions for saline laxatives?
Definition

1. Avoid in patients with renal insufficiency.

2. Avoid in patients with chronic heart failure.

3. Recommend against in Mg/phosphorus/Na restricted diets.

4. Mg products may lower absorption of some medications.

Term
What medications do magnesium-containing products lower the absorption of?
Definition

mycophenolate

doxycyline

ciprofloxacin

Term
List 2 advantages to saline laxatives.
Definition

Rapid onset of action

Cheap.

Term
List 2 disadvantages of saline laxatives.
Definition

May be absorbed systemically.

Electrolyte imbalance with chronic use.

Term
What are 2 counseling points to tell your patient who is taking saline laxatives?
Definition

1. Drink 8 oz of clear liquids with each dose.

2. Separate from other medications by 2 hours (to avoid DDI's)

Term
What should immediately come to mind when asked about oral saline laxatives?
Definition

Do NOT give OTC.

FDA placed a black box warning on oral sodium phosphate due to the accumulation of sodium or phosphate in the kidney causing acute kidney impairment.

Term
List 3 stimulant laxatives (both generic and brand names).
Definition

1. anthraquinone: Sennosides --> Senna ® or Senokot ®.

2. diphenylmethane: Bisacodyl --> Dulcolax ®

3. castor oil

Term
What is the mechanism of action for anthraquinone?
Definition
Metabolized by bacteria in the gut into the active form that stimulates colonic motility ("push").
Term
What is the onset of action for anthraquinones?
Definition
6 to 12 hours (may take up to 24 hrs).
Term
What is the dosing for anthraquinone?
Definition
8.6mg to 17.2mg PO QD.
Term
List 2 side effects of anthraquinone.
Definition

1. Bad abdominal cramping.

2. Urine discoloration.

Term
What is the mechanism of action of diphenylmethane?
Definition
Stimulates bowel motility by local irritation of the mucosa and increase secretion of fluids in the bowel.
Term
What is the onset of action for diphenylmethane?
Definition

Oral: 6 to 10 hours.

Rectal: 15 to 60 minutes.

Term
What is the dosing for diphenylmethane?
Definition
5 to 30mg daily.
Term
What are the side effects of diphenylmethane?
Definition
Really bad abdominal cramping (worse than Senna).
Term
What is an advantage of stimulant laxatives?
Definition
Minimal systemic absorption.
Term
What is a precaution for stimulant laxative use?
Definition
Continuous daily use can result in electrolyte and fluid deficiencies.
Term
What is a counseling point to tell a patient taking Bisacodyl?
Definition

Separate from antacids by atleast 1 hour.

Do not use with H2RA's and PPI's and/or milk.

(Bisacodyl is enterically coated, and will break down in the stomach instead of gut if pH of stomach is increased = MUCH greater abdominal cramping).

Term
What is the mechanism of action of castor oil?
Definition
Metabolized in the small intestine to ricinoleic acid (active form). MOA not well understood.
Term
What is the onset of action of castor oil?
Definition
2 to 6 hours.
Term
What is the dose of castor oil?
Definition
15 to 60 mL PO QD.
Term
What is a side effect of castor oil?
Definition
electrolyte imbalance.
Term
What is a precaution for castor oil?
Definition

Do NOT recommend to pregnant women.

(May stimulate uterine contraction and induce labor!!)

Term
What are 3 viable treatment options for children who suffer from constipation? (List age restrictions)
Definition

1. Barley malt extract (safe for infants).

2. Glycerin suppositories (less than 5 years old).

3. Miralax, milk of magnesia, magnesium citrate (okay for children over the age of 1 yr).

Term
List 3 treatments to avoid in children who suffer from constipation.
Definition

1. Mineral oil.

2. Stimulant laxatives.

3. Sodium phosphate enemas.

Term
Why are the elderly more prone to constipation?
Definition
Polypharmacy, Lifestyle, Diet, Medical conditions.
Term
What is worrisome about chronic laxative use in elderly patients?
Definition
Loss of fluid caused by aggressive laxative use.
Term
What are the 2 drugs of choice for preventing constipation in the elderly?
Definition

Bulk-forming agents

Docusate sodium

Term
What are the 4 drugs of choice for treating constipation in the elderly?
Definition

Glycerin suppositories.

Miralax (safe for cardiac/renal patients).

Senna

Saline enemas for acute episodes (only if rec by physician).

Term
What constipation drug should you avoid in the elderly?
Definition
mineral oil
Term
List 2 reasons why pregnant woman are more likely to become constipated.
Definition

1. Uterus compresses the colon.

2. Prenatal vitamins and mineral supplements (Ca, Fe).

Term
What should be the first-line of treatment for constipation in pregnant women?
Definition
Non-pharmacologic treatments! (increase fiber, exercise, fluid intake).
Term
What are the drugs of choice for treating constipation in pregnant women?
Definition

bulk-forming agents

docusate sodium

Term
What drugs should you avoid in pregnant women?
Definition

Mineral oil (interferes with vit absorption)

Castor oil (induction of labor)

Saline laxatives (systemic absorption)

Supporting users have an ad free experience!