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Coagulation Cascade - Fribrinolysis
Coagulation Cascade - Fribrinolysis
8
Medical
Undergraduate 2
03/26/2012

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Cards

Term
Antithrombin
Definition

serine protease inhibitor (SERPIN)

 

neutralizes thrombin and the intrinsic pathway

 

 

Term
Protein C & S
Definition

thrombin interacts with endothelial cell and produces the protein: thrombomodulin

this complex activates protein C zymogen

activated C binds with protein S

C-S complex inactivates factors Va and VIIIa

Term
Fibrinolysis
Definition

hydrolytic digestion of cross-linked fibrin polymers

 

occurs due to inactive proteolytic enyme incorporated into fibrin polymers

Term
Plasminogen
Definition

90,000 dalton zymogen that binds to fibrin during polymerization

 

capable of digesting fibrinogen and factors V & VIII

Term
Tissue Plasminogen Activator
Definition

produced and secreted by damaged endothelial cells and initiates fibrinolysis by converting plasminogen to plasmin

 

binds to fibrin during polymerization

 

 

Term
Plasminogen Activator Inhibitor I
Definition
secreted with TPA from endothelial cells
Term
Alpha-II-Antiplasmin
Definition

rapidly and irrevesibly binds free plasmin

 

ensures that fibrinogen and factors V & VIII are not hydrolyzed

Term
Fibrin Degradation Products
Definition

fragments of fibrin breakdown to inhibit any more clotting during fibrinolytic process

 

varities: X, Y, D, E, D-D

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