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clonal disorder bullshit lecture
clonal disorders
10
Medical
Professional
08/21/2011

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Term
what could you use for G6pd def screening
Definition
chromosomal lyonization is good for xlinked clonal disorder
Term
what could you use for CML?
Definition
karoytype, PCR, FISH
Term
what is karotype bad
Definition
must use dividing cells, take a lot of time
Term
what are pro/con of FISH
Definition
pro: reliable, faster, highly reproductible
-: lower SENSITIVITY, need specific probe availble for that. need specfic gene marker to probe for
Term
what would you use to look at b cell surface iGG?
Definition
can use PCR and use v/j recombination
Term
T/F PCR has low sensitivity for clonal b cell disorders?
Definition
False, high specificity
Term
what else is good to use for clonal bcell disorers besides PCR?
Definition
-protein electrophroesis to check for monoclonal gammopathies and immunofixation.
Term
when/why is it good to use flow cytometry?
Definition
-b lymphomas, can look as expression of individual light cahins, and can stain for specific cds
Term
what types of body fluids can you do immunofixation on?
Definition
urine and serum
Term
when else is good to do immunofixation besdies for b lymphomas?
Definition
amylodoises
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