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Clin Med Heme 2
Lymphomas Myelomas Leukemias PV
41
Medical
Graduate
02/15/2010

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Term
Hodgkin's Sympomts
Definition
Persistant painless lymphadenopathy
majority asymptomatic
Const Symp-- fever, night sweats, wt loss-- 25-30%
Pel-Ebstein Fever
Generalized Pruritis
Pain in lymph post-alcohol
herpes-zoster/mycofungal infections
Splenomegaly-- more in kids
Term
Hodgkin's Lymphoma distinctive cells
Definition
Reed-sternberg cells- OWL EYES
Term
Hodgkin's distribution
Definition
Bimodal Age distribution
M>W
Whites>AA
Younger in India-- EBV
Term
Hodgkin's Dx test
Definition
CBC, ESR, Serum Chemistry, LDH Level, Immunophenotyping, Lymph node histopathology
CXR, CT, PET, Gallium
Term
Hodgkin's Diagnostic Interpretations
Definition
Elevated ESR
Elevated LDH
Reed-sternberg cells
most cells are normal lymphoid, plasma cells, monocytes, and eosinophils
Term
Hodgkin's treatment plan
Definition
Combo Chemo most patients
-MOPP
-ABVD
-BEACOPP
Relapse after radiation-- chemo
Chemo + Radiation for bulky mass
Chemo for earlier stages in testing...
Term
Non-Hodgkin's Symptoms
Definition
Fever, anemia, infections
marked lymphadenopathy-- recurring
Const sympt-- fever, night sweats, wt loss (B sympt in high grade)
hepatosplenomegaly
Term
Non-Hodgkin's Diagnostic Interpretations
Definition
No Reed-sternberg cells or eosinophils
cytopenias
Chromosomal translocations
Waldeyer's ring-- GI
PBS normal but some lymphomas in leukemic phase
Serum LDH increased
CXR-- mediastinal mass
Term
Non-Hodgkin's distribution
Definition
common, 4th ranked hematology cancer
1:46M:56W (3:1, M:W)
Elderly
55-75 median age
Term
Non-Hodgkin's Diagnostic test
Definition
CBC, Chemistries, urinalysis, CT, Bone marrow biopsy/aspirate, lumbar puncture, PBS, Serum LDH, CXR
Term
Non-Hodgkin's Treatment
Definition
Chemo + Alkylating agents: Chlorambucil
+ CVP
Fludarabine
Rituximab-- salvage therapy
Short course chemo + CHOP + localized radiation
Chemo + CHOP for 6-8 cycles
CHOP + Rituximab for elderly
Term
allogenic transplantation
Definition
used for some patients with aggressive low grade lymphomas
Term
localized radiation
Definition
for patients with limited indolent disease (lymphoma)
Term
Multiple Myeloma Treatment that's potentially curable
Definition
potentially Curable w/High dose chemo (BM/SC transplant)
Term
Multiple Myeloma symptoms
Definition
20% asymptomatic
anemia
bone marrow failure
renal failure
recurrent infections
hyperviscosity syndrome
Proximal renal tubular acidosis
Term
Multiple Myeloma Epidemiology
Definition
average age 65
Males>Females
Blacks 2x> Whites
5 year survival-- 25-30%
Medial survival-- 30-36 mos
Term
Multiple Myeloma Diagnostic Interpretations
Definition
Thrombocytopenia
Neutropenia
Amyloidosis
Lytic lesions
Decreased bone density
hypercalcemia
RBC normal with Rouleau formation
Neutrophil/Platelet normal AT FIRST
Proteinuria-- Bence Jones Proteins
ESR Elevated
PBS-- plasma cells rarely visible
SPEP-- Paraprotein
IgG Production
Phosphaturia, glycosuria, uricosuria, aminoaciduria
BM biopsy w/5-100% infiltrate plasma cells
Deletion of 13q chromosome
Term
Multiple Myeloma diagnostic testing
Definition
Bone X-rays
IEP, Urine IEP
SPEP
Bone marrow biopsy
PBS
ESR
Term
Multiple Myeloma Treatments
Definition
-Combo Chemo + VAD
-Thalidomide and thalidomide derivatives and experimental agents CC-5013 and PS-341
-Thalidomide, berexomib (PS-341, Velcade), and the experimental agent CC-5013 (Revimid)
-Mobilization, hydration, and bisphosphonates for hypercalcemia
-Bisphosphonates (eg, pamidronate, 90 mg, or zoledronate, 4 mg IV Q month) to reduce pathological fractures
Term
Multiple Myeloma chronic treatment
Definition
-Autologous stem cell transplantation in patients aged <70
-Autologous transplantation useful in relapse if disease still chemotherapy sensitive
-Allogeneic transplantation potentially curative, but role limited by unusually high mortality rate
Term
ALL epidemiology
Definition
5/100,000 people
most common pediatric cancer
peak 2-6 years
Males, Whites, Jews
Term
ALL Diagnostic interpretations
Definition
leukemic cells in BM
Anemia, thrombocytopenia, neutropenia
WBC vary
>25% leukemic blast cells
hyperuricemia
hypomagnesemia
hypocalcemia/hypercalcemia
low serum immunoglobulins
Term
ALL symptoms
Definition
fatigue, pallor, bleeding, infection (respiratory, dental, perirectal, sinus, UTI)
Hepatosplenomegaly
testes enlargement
mimic RA
CNS-- vomiting, headache, papilledema, neck stiffness, cranial nerve palsy
Term
ALL Acute treatment plan
Definition
Radiation therapy
TBI-- for BMT
Chemo
BMT
Term
AML Epidemiology
Definition
5x more than ALL
equally at all ages, slightly more common >50
-elderly 19/100,000
80% of adult leukemia
4.6(M):3.0(W)/100,000
Term
AML Symptoms
Definition
increased fatigue
decreased exercise tolerance
excess bleeding
fevers/recurrent infections
headache, vision changes
early satiety
history of cancer/smoking
petechiae, purpura
splenomegaly
Term
AML diagnostic interpretations
Definition
neutropenia
Abn Blood count-- thrombocytopenia
leukocytosis, anemia
Chromosomal abnormality
Auer rods
BM w/30% blast cells
Term
AML treatment
Definition
M3-- retinoic acid (vit a derivative)
combo chemo, radiation, BMT
Term
CLL diagnostic interpretations
Definition
Chromosomal deletion at 13q14
Term
CLL epidemiology
Definition
most common leukemia
increase with age
median 65, rare under 35
Men>Women
White>blacks
uncommon in asia
Term
CLL Symptoms
Definition
new lymphadenopathy
fatigue
frequent infections
bone pain
excessive sweating
generalized pruritis- after shower
easy bruising
splenomegaly
Term
CLL diagnostic interpretations
Definition
Lymphocytes >10,000
^ leukemic cells in BM, blood, LN, spleen
lymphocytosis
anemia, thrombocytopenia
CD5/23 (30% have 38)
Term
CLL treatment
Definition
no optimal treatment
Chemo for thrombocytopenia/anemia
Radiation palliative care for localized tumors
Splenectomy for cytopenia
Term
CML diagnostic interpretations
Definition
Philadelphia chromosome
anemia, thrombocytopenia
leukocytosis
myeloblasts, promyelocytes, reticulocytes
Serum B12 elevated
Decreased LAP score
BM-- granulocytic/megakaryocytic hyperplasia
Left shift on CBC
Term
CML epidemiology
Definition
20-30% of leukemias
Rare in children, uncommon before 21
Peaks mid 40's
Males slightly more common
Term
CML symptoms
Definition
malaise, fatigue, sweating, heat intolerance, easy bruising
wt loss, peripheral leg edema
splenomegaly-- progressive/painful
LUQ discomfort
early satiety
fever, bone pain, and wt loss from blast crisis
Term
CML treatment
Definition
Imatinab (Gleevec) 400mg/d PO
Radiation-- TBI/spleen
Chemo
SCT
Term
Polycythemia Vera Epidemiolgoy
Definition
2/100,000 people
increase with age
median 60 yrs old
peak 50-70 yrs old
men 2x> women (except during reproduction age)
Term
Polycythemia Vera Symptoms
Definition
neurologic: vertigo, tinnitus, headache, visual disturbances, transient ischemic attack
Venous/arterial thrombosi: Hempatic ven thrombosis/Budd-Chiari Syndrome, MI, stroke, peripheral vascular disease
Massive splenomegaly
Aquagenic pruritis
Easy bruising
Erythromelalgia: burning, throbbing, reddness of LE/hands; feet/lower legs flushed and warm; acral parasthesis
Term
Polycythemia Vera Diagnostic interpretations
Definition
Elevated red cell mass (>36M, >32W)
leukocytosis
thrombocytosis
LAP increased
B12 increased
Normal O2 saturation
CBC: elevated Hgb, Hct, RBC #
MCV decreased
Platelet/Leukocyte elevated
Plasma EPO LOW
Granulocyte alkaline phosphate level elevated
tisomy 8 or 9
20q-
Term
Polycythemia Vera treatments
Definition
phlebotomy
maintain hgb at 14M and 12W
Others:
hydroxyurea
interferon a
allogenic BM for young patients
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